Parkinson Disease and Complex Parkinsonism
Gene: LYSTComment on list classification: Changed Amber to Green from external review comment and internal clinical review and is appropriate to have on the parkinsonims panel as some subclinical forms ofCreated: 24 Jul 2018, 12:19 p.m.
Comment on mode of inheritance: Confirmed in OMIM and publications.Created: 1 Jun 2018, 12:20 p.m.
Comment on list classification: This gene was added by a reviewer. More than 3 cases reported for variants in this gene and Chediak-Higashi syndrome. Clinical synposis for this disorder in OMIM includes Progressive intellectual decline, Neurodegeneration, Tremor, Progressive peripheral neuropathy. Awaiting confirmation from the internal Genomics England team that this gene is suitable to be made green on this panel.Created: 1 Jun 2018, 12:20 p.m.
multiple case reports of Parkinsonism in Chediak-Higashi syndrome.Created: 16 Apr 2018, 9:29 p.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Parkinsonism; albinism; peripheral neuropathy
Publications
Gene: lyst has been classified as Green List (High Evidence).
Mode of inheritance for gene: LYST was changed from BIALLELIC, autosomal or pseudoautosomal to BIALLELIC, autosomal or pseudoautosomal
Gene: lyst has been classified as Amber List (Moderate Evidence).
Publications for gene: LYST were set to 23436631; 8896560; 9215679; 9215680; 11857544
Publications for gene: LYST were set to 23436631; 8896560; 9215679; 9215680
Publications for gene: LYST were set to 23436631; 8896560; 9215679
Publications for gene: LYST were set to 23436631; 8896560
Phenotypes for gene: LYST were set to Parkinsonism; albinism; peripheral neuropathy; Chediak-Higashi syndrome 214500
LYST was added to Parkinson Disease and Complex Parkinsonism panel. Sources: Other
LYST was created by alisdair mcneill