Familial Meniere Disease

Gene: ADD2

Red List (low evidence)

ADD2 (adducin 2)
EnsemblGeneIds (GRCh38): ENSG00000075340
EnsemblGeneIds (GRCh37): ENSG00000075340
OMIM: 102681, Gene2Phenotype
ADD2 is in 1 panel

1 review

Eldar Dedic (Independent Clinical Genetics Consultant)

Red List (low evidence)

- No Meniere disease patient with rare ADD2 variant has been found through literature search

- There are no likely pathogenic/pathogenic variants within ADD2 according to ClinVar

- This gene is having pLI score of 1 (gnomAD v2.1.1) and an HI score of 37.61% (Decipher)

- There are no high frequency potentially loss of function (pLOF) variants (gnomAD v2.1.1)

- There are no high-frequency pLOF copy number variants reported by gnomAD SV v2.1 or DGV Gold Standard Variants

- No model associating this gene with hearing loss has been reported in publications or by MGI, IMPC, or Alliance

- OMIM and Orphanet did not associate this gene with any phenotype
Created: 10 Oct 2021, 12:17 p.m. | Last Modified: 10 Oct 2021, 12:17 p.m.
Panel Version: 1.1

Mode of inheritance


  • Literature
Clinvar variants
Variants in ADD2
Panels with this gene

History Filter Activity

27 Mar 2018, Gel status: 1

Panel promoted to version 1.0

Eleanor Williams (Genomics England Curator)

External reviews collated. Internal clinical input. Ready for version 1.

17 Jan 2018, Gel status: 1

Added New Source

Eleanor Williams (Genomics England Curator)

ADD2 was added to Familial Meniere Disease panel. Sources: Literature

17 Jan 2018, Gel status: 1


Eleanor Williams (Genomics England Curator)

ADD2 was created by Eleanor Williams