Familial Meniere Disease

Gene: HLA-DRB1

Red List (low evidence)

HLA-DRB1 (major histocompatibility complex, class II, DR beta 1)
EnsemblGeneIds (GRCh38): ENSG00000196126
EnsemblGeneIds (GRCh37): ENSG00000196126
OMIM: 142857, Gene2Phenotype
HLA-DRB1 is in 4 panels

2 reviews

Eleanor Williams (Genomics England Curator)

Comment on list classification: The allele HLA-DRB1*1101 was associated with bilateral MD in a Mediterranean population (43 individuals) but this association not replicated in a cohort from northern Spain (37 individuals) (PMID: 17592398) or in a group of 168 patients with bilateral MD (PMID:25397881). In a study with a Korean population significantly higher frequency of HLA-DRB1*15 was found (39 individuals) (PMID:12542204). No statistically significant association found in HLA-DRB1 alleles in another Korean study (41 individuals)(PMID:12622783)
21 Mar 2018, 11:38 a.m.

Jose Antonio Lopez-Escamez (Center for Genomic GENyO)

Red List (low evidence)

Previous association with this gene in bilateral Meniere disease has not been replicated in larger cohort of MD
20 Feb 2018, 5:55 p.m.

Publications

History Filter Activity

27 Mar 2018, Gel status: 1

Panel promoted to version 1.0

Eleanor Williams (Genomics England Curator)

External reviews collated. Internal clinical input. Ready for version 1.

21 Mar 2018, Gel status: 1

Set publications

Eleanor Williams (Genomics England Curator)

Publications for HLA-DRB1 were set to 28787010; 17592398; 25397881; 12189399; 12542204; 12622783

21 Mar 2018, Gel status: 1

Set publications

Eleanor Williams (Genomics England Curator)

Publications for HLA-DRB1 were set to 28787010; 17592398; 25397881; 12189399; 12542204

21 Mar 2018, Gel status: 1

Set publications

Eleanor Williams (Genomics England Curator)

Publications for HLA-DRB1 were set to 28787010; 17592398; 25397881; 12189399

21 Mar 2018, Gel status: 1

Gene classified by Genomics England curator

Eleanor Williams (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

21 Mar 2018, Gel status: 1

Gene classified by Genomics England curator

Eleanor Williams (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

21 Mar 2018, Gel status: 1

Set publications

Eleanor Williams (Genomics England Curator)

Publications for HLA-DRB1 were set to 28787010; 17592398; 25397881

17 Jan 2018, Gel status: 1

Added New Source

Eleanor Williams (Genomics England Curator)

HLA-DRB1 was added to Familial Meniere Disease panel. Sources: Literature

17 Jan 2018, Gel status: 1

Created

Eleanor Williams (Genomics England Curator)

HLA-DRB1 was created by Eleanor Williams