Familial Meniere DiseaseGene: WFS1
Added watchlist tag as new data about this gene may be available soon.
Created: 22 Mar 2018, 2:51 p.m.
Comment on list classification: Jose Antonio Lopez-Escamez confirmed that he has unpublished data on 2 different novel variants that have been found in 6 non-related individuals with sporadic Meniere disease (one variant in 2 individuals, the other in 4 individuals). These variants have to be validated. Rating this gene as red, but with a watchlist tag, until more evidence is available.
Created: 22 Mar 2018, 2:34 p.m.
Comment on mode of inheritance: MOI added following reviewer comment
Created: 21 Mar 2018, 3:42 p.m.
Several sporadic patients are carriers of rara variants in this gene (unpublished findings)
Created: 5 Mar 2018, 3:55 p.m.
Mode of inheritance
Sporadic Meniere disease
Variants in this GENE are reported as part of current diagnostic practice
External reviews collated. Internal clinical input. Ready for version 1.
This gene has been classified as Red List (Low Evidence).
Mode of inheritance for WFS1 was changed from to Unknown
Phenotypes for WFS1 were set to Sporadic Meniere disease
WFS1 was added to Familial Meniere Disease panel. Sources: Literature
WFS1 was created by Eleanor Williams