Thyroid cancer pertinent cancer susceptibility
Gene: CDKN1BComment on mode of inheritance: Changed MOI from 'biallelic to 'monoallelic'. Literature review did not indicate presence of biallelic variants pertaining to thyroid or parathyroid tumours. The MOI for this gene is also monoallelic in OMIM and other PanelApp panels.Created: 24 Sep 2021, 11 a.m. | Last Modified: 24 Sep 2021, 11 a.m.
Panel Version: 1.3
Mode of inheritance for gene: CDKN1B was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: CDKN1B were changed from Thyroid cancer; Pituitary adenoma to Multiple endocrine neoplasia, type IV, OMIM:610755; Thyroid cancer; Pituitary adenoma
Mode of inheritance for gene: CDKN1B was changed from BIALLELIC, autosomal or pseudoautosomal to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
This Cancer Germline 100K panel has been subjected to extensive internal and external review and has been versioned to V1 to enable germline reporting in the Cancer Pipeline.
Publications for gene: CDKN1B were set to 17030811
Gene: cdkn1b has been classified as Green List (High Evidence).
CDKN1B was added to Thyroid cancer pertinent cancer susceptibility panel. Sources: Expert list
CDKN1B was created by Ellen McDonagh