Sudden death in young people
Gene: FEV
FEV (FEV, ETS transcription factor)
EnsemblGeneIds (GRCh38): ENSG00000163497
EnsemblGeneIds (GRCh37): ENSG00000163497
OMIM: 607150, Gene2Phenotype
FEV is in 1 panel
EnsemblGeneIds (GRCh38): ENSG00000163497
EnsemblGeneIds (GRCh37): ENSG00000163497
OMIM: 607150, Gene2Phenotype
FEV is in 1 panel
1 review
Rebecca Foulger (Genomics England curator)
Comment on list classification: Changed rating from red to grey: PMID:17597646 reports 3 polymorphisms in the FEV gene (two in exon 3, and one in the preceeding intron) but they are found in both SIDS cases and matched controls. They also report a heterozygous insertion mutation (IVS-191_190insA) upstream of the 5' exon 3 splice site in the FEV gene, which is unique to African-American SIDS cases. However PMID:19707175 report that this insertion polymorphism seems to be a common, likely nonpathogenic, variant in the African-American population.Created: 6 Dec 2016, 4:33 p.m.
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
- Sources
-
- Expert Review Removed
- Literature
- Phenotypes
-
- SIDS
- Sudden infant death syndrome
- Tags
- OMIM
- 607150
- Clinvar variants
- Variants in FEV
- Penetrance
- Complete
- Panels with this gene
History Filter Activity
26 Feb 2021, Gel status: 0
Added Tag
Arina Puzriakova (Genomics England Curator)Tag curated_removed tag was added to gene: FEV.
19 Dec 2016, Gel status: 0
panel promoted to version 1
Ellen Thomas (Genomics England Curator)This panel contains genes which aren't arrhythmic or metabolic causes of sudden death with normal post mortem.
6 Dec 2016, Gel status: 0
Gene classified by Genomics England curator
Rebecca Foulger (Genomics England curator)This gene has been removed from the panel.
6 Dec 2016, Gel status: 0
Created
Rebecca Foulger (Genomics England curator)FEV was created by rfoulger
6 Dec 2016, Gel status: 0
Added New Source
Rebecca Foulger (Genomics England curator)FEV was added to Sudden death in young peoplepanel. Sources: Literature