Sudden death in young peopleGene: SLC6A4
SLC6A4 (5-HTT) may be a risk factor for sudden death: polymorphisms in the 5' regulatory region differ between SIDS victims and controls; In a haplotype analysis, PMID:12966525 showed that an intron 2 polymorphism (12-repeat allele), which also differentially regulates 5-HTT expression, was associated with increased risk of SIDS in African American but not Caucasian SIDS cases.
Created: 29 Nov 2016, 10:16 a.m.
Mode of pathogenicity
This panel contains genes which aren't arrhythmic or metabolic causes of sudden death with normal post mortem.
SLC6A4 was created by rfoulger
SLC6A4 was added to Sudden death in young peoplepanel. Sources: Literature