White matter disorders and cerebral calcification - narrow panel
Gene: ZFYVE26
The rating of this gene has been updated to Green following NHS Genomic Medicine Service approval.Created: 30 Jan 2023, 4:26 p.m. | Last Modified: 30 Jan 2023, 4:26 p.m.
Panel Version: 2.9
Comment on list classification: Promoted Red to Amber. This gene is associated with a relevant phenotype in OMIM and Gene2Phenotype. This gene is Green on the White matter disorders - adult onset (Version 1.10) panel. The age of onset can be in childhood. This gene should be Green at the next review.Created: 13 May 2021, 8:56 a.m. | Last Modified: 13 May 2021, 8:56 a.m.
Panel Version: 1.90
Complex spastic paraplegia, including white matter changes. Variable age of onset ranging from paediatric to adult.Created: 16 Sep 2020, 5:45 a.m. | Last Modified: 16 Sep 2020, 5:45 a.m.
Panel Version: 1.14
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Spastic paraplegia 15, autosomal recessive, MIM# 270700
Publications
Tag Q2_21_rating was removed from gene: ZFYVE26.
Source NHS GMS was added to ZFYVE26. Source Expert Review Green was added to ZFYVE26. Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Gene: zfyve26 has been classified as Amber List (Moderate Evidence).
Tag Q2_21_rating tag was added to gene: ZFYVE26.
Phenotypes for gene: ZFYVE26 were changed from Spastic paraplegia 15, autosomal recessive, MIM#270700 to Spastic paraplegia 15, autosomal recessive, OMIM:270700
Publications for gene: ZFYVE26 were set to
Checked against super panel made up of the panel constituents. Ready to promote to version 1
gene: ZFYVE26 was added gene: ZFYVE26 was added to White matter disorders and cerebral calcification - narrow panel. Sources: Expert Review Red Mode of inheritance for gene: ZFYVE26 was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: ZFYVE26 were set to Spastic paraplegia 15, autosomal recessive, MIM#270700