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  3. DNAH9
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Haematological malignancies cancer susceptibility

Gene: DNAH9

Amber List (moderate evidence)
DNAH9 (dynein axonemal heavy chain 9)
EnsemblGeneIds (GRCh38): ENSG00000007174
EnsemblGeneIds (GRCh37): ENSG00000007174
OMIM: 603330, Gene2Phenotype
DNAH9 is in 6 panels

2 reviews

Sarah Leigh (Genomics England Curator)

Green List (high evidence)

In a study of myelodysplastic syndrome (MDS) acute myeloid leukemia (AML) patients, Rio-Machin et al (PMID: 32098966) reports five DNAH9 variants in three unrelated families with MDS and / or AML.
Created: 7 May 2025, 4:34 p.m. | Last Modified: 7 May 2025, 4:34 p.m.
Panel Version: 4.15

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Created: 7 May 2025, 4:34 p.m.
Last Modified: 7 May 2025, 4:34 p.m.
Panel version: 4.15

Lauma Freimane (Children's Clinical University Hospital)

Green List (high evidence)

Sources: Literature
Created: 19 Jun 2023, 1:06 p.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
MDS/AML; inherited bone marrow failure (IBMF)

Publications

Created: 19 Jun 2023, 1:06 p.m.

Panel version: 4.2

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Amber
Phenotypes
  • MDS/AML
  • inherited bone marrow failure (IBMF)
Tags
Q2_25_ promote_green
OMIM
603330
Clinvar variants
Variants in DNAH9
Penetrance
None
Publications
Panels with this gene

History Filter Activity

7 May 2025, Gel status: 2

Added Tag

Sarah Leigh (Genomics England Curator)

Tag Q2_25_ promote_green tag was added to gene: DNAH9.

7 May 2025, Gel status: 2

Set publications

Sarah Leigh (Genomics England Curator)

Publications for gene: DNAH9 were set to 32098966; 26492932

7 May 2025, Gel status: 2

Set publications

Sarah Leigh (Genomics England Curator)

Publications for gene: DNAH9 were set to 32098966

7 May 2025, Gel status: 2

Entity classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

Gene: dnah9 has been classified as Amber List (Moderate Evidence).

19 Jun 2023, Gel status: 0

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Lauma Freimane (Children's Clinical University Hospital)

gene: DNAH9 was added gene: DNAH9 was added to Haematological malignancies cancer susceptibility. Sources: Literature Mode of inheritance for gene: DNAH9 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: DNAH9 were set to 32098966 Phenotypes for gene: DNAH9 were set to MDS/AML; inherited bone marrow failure (IBMF) Review for gene: DNAH9 was set to GREEN