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Haematological malignancies cancer susceptibility

Gene: NAF1

Green List (high evidence)
NAF1 (nuclear assembly factor 1 ribonucleoprotein)
EnsemblGeneIds (GRCh38): ENSG00000145414
EnsemblGeneIds (GRCh37): ENSG00000145414
NAF1 is in 3 panels

3 reviews

Eleanor Williams (Genomics England Curator)

Removed the new-gene-name tag. The HGNC name for ENSG00000145414/HGNC:25126 is still NAF1. NAF1 is an alias symbol for another gene TNIP1 (ENSG00000145901/HGNC:16903) though.
Created: 7 May 2022, 10:57 p.m. | Last Modified: 7 May 2022, 10:57 p.m.
Panel Version: 2.30
Created: 7 May 2022, 10:57 p.m.
Last Modified: 7 May 2022, 10:57 p.m.
Panel version: 2.30

Arina Puzriakova (Genomics England Curator)

Added 'new-gene-name' tag. The HGNC symbol for this gene is TNIP1.
Created: 21 Jan 2022, 10:24 a.m. | Last Modified: 21 Jan 2022, 10:24 a.m.
Panel Version: 2.21
Created: 21 Jan 2022, 10:24 a.m.
Last Modified: 21 Jan 2022, 10:24 a.m.
Panel version: 2.21

Clare Turnbull (Queen Mary University London)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Created: 26 Jul 2017, 11:15 a.m.

Panel version: 0.8

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Green
  • Curated sources
Phenotypes
  • Class: BM failure syndrome (typ AR)
  • Dyskeratosis congenita
  • MDS, AML
  • Oral and GI squamous cell carcinoma
Clinvar variants
Variants in NAF1
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

20 Mar 2026, Gel status: 3

Removed Tag

Ida Ertmanska (Genomics England Curator)

Tag gene-checked was removed from gene: NAF1.

7 May 2022, Gel status: 3

Removed Tag, Added Tag

Eleanor Williams (Genomics England Curator)

Tag new-gene-name was removed from gene: NAF1. Tag gene-checked tag was added to gene: NAF1.

7 May 2022, Gel status: 3

Set publications

Eleanor Williams (Genomics England Curator)

Publications for gene: NAF1 were set to 28297620

21 Jan 2022, Gel status: 3

Added Tag

Arina Puzriakova (Genomics England Curator)

Tag new-gene-name tag was added to gene: NAF1.

7 Sep 2018, Gel status: 4

Panel promoted to version 1.0

Louise Daugherty (Genomics England Curator)

Ellen McDonagh: Comment on mode of inheritance

30 Jan 2018, Gel status: 4

Added New Source

Ellen McDonagh (Genomics England Curator)

Expert Review Green was added to NAF1. Panel: Haematological malignancies pertinent cancer susceptibility

21 Jun 2017, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

NAF1 was added to Haematological malignanciespanel. Sources: Curated sources

21 Jun 2017, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

NAF1 was created by ellenmcdonagh