Haematological malignancies cancer susceptibility
Gene: TERC

TERC (telomerase RNA component)
EnsemblGeneIds (GRCh38): ENSG00000270141
EnsemblGeneIds (GRCh37): ENSG00000270141
OMIM: 602322, Gene2Phenotype
TERC is in 15 panels

2 reviews

Ellen McDonagh (Genomics England Curator)

Comment on list classification: This gene has now been implemented into the pipeline.
Created: 27 Jul 2018, 3:47 p.m.

Comment on list classification: This gene was removed from the Green list as it is not a protein-coding gene.
Created: 16 Mar 2018, 9:55 a.m.

Created: 16 Mar 2018, 9:55 a.m.

Panel version: 0.22

Clare Turnbull (Queen Mary University London)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Created: 26 Jul 2017, 11:15 a.m.

Panel version: 0.8

Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Sources

Expert Review Green
Curated sources

Phenotypes

Class: BM failure syndrome (typ AR)
Dyskeratosis congenita
MDS, AML
Bone marrow failure, macrocytosis
Skin, head and neck, and anogenital squamous cell cancers, Oral and GI squamous cell carcinoma

Tags

locus-type-rna-long-non-coding

OMIM

602322

Clinvar variants

Variants in TERC

Penetrance

Complete

Publications

Panels with this gene

History Filter Activity

29 Jul 2024, Gel status: 3

Added Tag

Sarah Leigh (Genomics England Curator)

Tag locus-type-rna-long-non-coding tag was added to gene: TERC.

7 Sep 2018, Gel status: 3

Panel promoted to version 1.0

Louise Daugherty (Genomics England Curator)

Ellen McDonagh: Comment on list classification

27 Jul 2018, Gel status: 3