Periodic fever syndromes

Gene: LYZ

Green List (high evidence)

LYZ (lysozyme)
EnsemblGeneIds (GRCh38): ENSG00000090382
EnsemblGeneIds (GRCh37): ENSG00000090382
OMIM: 153450, Gene2Phenotype
LYZ is in 4 panels

1 review

Alice Gardham (Genomics England)

Green List (high evidence)

Reported in at least 11 families
Created: 1 Feb 2017, 2:42 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Amyloidosis, renal 105200

Publications

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Eligibility statement prior genetic testing
  • Illumina TruGenome Clinical Sequencing Services
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • Amyloidosis, renal, 105200
  • Familial Visceral Amyloidosis
OMIM
153450
Clinvar variants
Variants in LYZ
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

22 Feb 2017, Gel status: 4

panel promoted to version 1

Rebecca Foulger (Genomics England curator)

22nd February 2017: Promoted to V1. Panel was reviewed by Tracy Briggs and Alice Gardham. Panel was revised according to expert review and additional curation.

22 Feb 2017, Gel status: 4

Set Mode of Inheritance

Rebecca Foulger (Genomics England curator)

Mode of inheritance for LYZ was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

2 Feb 2017, Gel status: 4

Gene classified by Genomics England curator

Alice Gardham (Genomics England)

This gene has been classified as Green List (High Evidence).

2 Feb 2017, Gel status: 4

Set publications

Alice Gardham (Genomics England)

Publications for LYZ were set to 8464497; 20301373; 16523055

1 Feb 2017, Gel status: 4

Gene classified by Genomics England curator

Alice Gardham (Genomics England)

This gene has been classified as Green List (High Evidence).

1 Feb 2017, Gel status: 4

Set publications

Alice Gardham (Genomics England)

Publications for LYZ were set to 8464497; 20301373; 16523055

1 Feb 2017, Gel status: 4

Gene classified by Genomics England curator

Alice Gardham (Genomics England)

This gene has been classified as Green List (High Evidence).

12 Aug 2015, Gel status: 2

Added New Source

Ellen McDonagh (Genomics England Curator)

LYZ was added to Periodic fever syndromes and amyloidosis panel. Sources: Eligibility statement prior genetic testing

15 Jul 2015, Gel status: 2

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene LYZ was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

15 Jul 2015, Gel status: 2

Added New Source

Ellen McDonagh (Genomics England Curator)

LYZ was added to Periodic fever syndromes and amyloidosis panel. Sources: Radboud University Medical Center, Nijmegen,Illumina TruGenome Clinical Sequencing Services,Eligibility Statements for GeL

15 Jul 2015, Gel status: 2

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene LYZ was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

15 Jul 2015, Gel status: 2

Added New Source

Ellen McDonagh (Genomics England Curator)

LYZ was added to Periodic fever syndromes and amyloidosis panel. Sources: Radboud University Medical Center, Nijmegen,Illumina TruGenome Clinical Sequencing Services,Eligibility Statements for GeL

15 Jul 2015, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

LYZ was added to Periodic fever syndromes and amyloidosis panel. Sources: Radboud University Medical Center, Nijmegen,Illumina TruGenome Clinical Sequencing Services,Eligibility Statements for GeL