Periodic fever syndromes

Gene: TNFRSF1A

Green List (high evidence)

TNFRSF1A (TNF receptor superfamily member 1A)
EnsemblGeneIds (GRCh38): ENSG00000067182
EnsemblGeneIds (GRCh37): ENSG00000067182
OMIM: 191190, Gene2Phenotype
TNFRSF1A is in 5 panels

3 reviews

Alice Gardham (Genomics England)

Comment on list classification: Royal Free Periodic Fever service reports reduced penetrance
Created: 2 Feb 2017, 10:38 a.m.

Rebecca Foulger (Genomics England curator)

Comment on list classification: Updated rating from Red to Green: 1 External green review. Plus >3 unrelated cases in OMIM for TNFRSF1A variants causing periodic fever (OMIM:142680). Plus recommended for prior genetic testing.
Created: 12 Jan 2017, 11:48 a.m.
Comment on mode of inheritance: Mode of inheritance confirmed by OMIM.
Created: 12 Jan 2017, 11:43 a.m.

Tracy Briggs (Manchester Genomic Medicine Centre)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Eligibility statement prior genetic testing
  • Emory Genetics Laboratory
Phenotypes
  • Hereditary Periodic Fever Syndromes
  • Periodic fever, familial, 142680
OMIM
191190
Clinvar variants
Variants in TNFRSF1A
Penetrance
Incomplete
Publications
Panels with this gene

History Filter Activity

22 Feb 2017, Gel status: 4

panel promoted to version 1

Rebecca Foulger (Genomics England curator)

22nd February 2017: Promoted to V1. Panel was reviewed by Tracy Briggs and Alice Gardham. Panel was revised according to expert review and additional curation.

2 Feb 2017, Gel status: 4

Gene classified by Genomics England curator

Alice Gardham (Genomics England)

This gene has been classified as Green List (High Evidence).

30 Jan 2017, Gel status: 4

Gene classified by Genomics England curator

Alice Gardham (Genomics England)

This gene has been classified as Green List (High Evidence).

12 Jan 2017, Gel status: 4

Gene classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

This gene has been classified as Green List (High Evidence).

12 Jan 2017, Gel status: 1

Set Mode of Inheritance

Rebecca Foulger (Genomics England curator)

Mode of inheritance for TNFRSF1A was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

12 Jan 2017, Gel status: 1

Set Phenotypes

Rebecca Foulger (Genomics England curator)

Phenotypes for gene TNFRSF1A were set to Hereditary Periodic Fever Syndromes; Periodic fever, familial, 142680

12 Aug 2015, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

TNFRSF1A was added to Periodic fever syndromes and amyloidosis panel. Sources: Eligibility statement prior genetic testing

15 Jul 2015, Gel status: 1

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene TNFRSF1A was changed to Unknown

15 Jul 2015, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

TNFRSF1A was added to Periodic fever syndromes and amyloidosis panel. Sources: Emory Genetics Laboratory,Eligibility Statements for GeL

15 Jul 2015, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

TNFRSF1A was added to Periodic fever syndromes and amyloidosis panel. Sources: Emory Genetics Laboratory,Eligibility Statements for GeL