Periodic fever syndromes
Gene: TNFRSF1AComment on list classification: Royal Free Periodic Fever service reports reduced penetranceCreated: 2 Feb 2017, 10:38 a.m.
Comment on list classification: Updated rating from Red to Green: 1 External green review. Plus >3 unrelated cases in OMIM for TNFRSF1A variants causing periodic fever (OMIM:142680). Plus recommended for prior genetic testing.Created: 12 Jan 2017, 11:48 a.m.
Comment on mode of inheritance: Mode of inheritance confirmed by OMIM.Created: 12 Jan 2017, 11:43 a.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: TNFRSF1A were changed from Hereditary Periodic Fever Syndromes; Periodic fever, familial, 142680 to Periodic fever, familial, OMIM:142680
22nd February 2017: Promoted to V1. Panel was reviewed by Tracy Briggs and Alice Gardham. Panel was revised according to expert review and additional curation.
This gene has been classified as Green List (High Evidence).
This gene has been classified as Green List (High Evidence).
This gene has been classified as Green List (High Evidence).
Mode of inheritance for TNFRSF1A was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene TNFRSF1A were set to Hereditary Periodic Fever Syndromes; Periodic fever, familial, 142680
TNFRSF1A was added to Periodic fever syndromes and amyloidosis panel. Sources: Eligibility statement prior genetic testing
Model of inheritance for gene TNFRSF1A was changed to Unknown
TNFRSF1A was added to Periodic fever syndromes and amyloidosis panel. Sources: Emory Genetics Laboratory,Eligibility Statements for GeL
TNFRSF1A was added to Periodic fever syndromes and amyloidosis panel. Sources: Emory Genetics Laboratory,Eligibility Statements for GeL