Endocrine neoplasms

Gene: AIP

Green List (high evidence)

AIP (aryl hydrocarbon receptor interacting protein)
EnsemblGeneIds (GRCh38): ENSG00000110711
EnsemblGeneIds (GRCh37): ENSG00000110711
OMIM: 605555, Gene2Phenotype
AIP is in 5 panels

5 reviews

Ivone Leong (Genomics England Curator)

Comment when marking as ready: As discussed in the GMS Endocrinology Specialist Test Group webex call 28th Jan 2019: The Specialist Test Group agreed that there is enough evidence to rate this gene green.
Created: 11 Mar 2019, 2:04 p.m.

Louise IZATT (GSTT Clinical Genetics Service)

Green List (high evidence)

Katie Snape (South London GMC)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Variants in this GENE are reported as part of current diagnostic practice

Treena Cranston (Oxford)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Sian Ellard (University of Exeter Medical School)

Green List (high evidence)

An approved UKGTN test
Created: 19 Aug 2015, 9:12 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Variants in this GENE are reported as part of current diagnostic practice

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • NHS GMS
Phenotypes
  • Endocrine Cancer
  • Pituitary adenoma, growth hormone-secreting, 102200
  • pituitary tumours
  • Familial Isolated Pituitary Adenomas
  • Pituitary adenoma, prolactin-secreting, 600634
  • Pituitary adenoma, ACTH-secreting, 219090
OMIM
605555
Clinvar variants
Variants in AIP
Penetrance
None
Panels with this gene

History Filter Activity

11 Mar 2019, Gel status: 3

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: aip has been classified as Green List (High Evidence).

11 Mar 2019, Gel status: 4

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Ivone Leong (Genomics England Curator)

gene: AIP was added gene: AIP was added to Endocrine neoplasms. Sources: Expert Review Green,NHS GMS Mode of inheritance for gene: AIP was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: AIP were set to Endocrine Cancer; Pituitary adenoma, growth hormone-secreting, 102200; pituitary tumours; Familial Isolated Pituitary Adenomas; Pituitary adenoma, prolactin-secreting, 600634; Pituitary adenoma, ACTH-secreting, 219090