Endocrine neoplasia
Gene: TP53
After NHS Genomic Medicine Service consideration, the rating of this gene has not been changed.Created: 3 Mar 2022, 1:36 p.m. | Last Modified: 3 Mar 2022, 1:37 p.m.
Panel Version: 1.25
This gene was proposed to be added to this panel with Green status by Soo-Mi Park (East Anglian Medical Genetics Service). No further evidence was provided.
This gene is Green on the Multiple endocrine tumours (Version 1.9) panel.
This gene has been added as an Amber gene and will be given Green status pending decision by the GMS review panel.
Sources: Expert ReviewCreated: 28 Jan 2021, 10:28 a.m. | Last Modified: 16 Feb 2021, 10:14 a.m.
Panel Version: 1.14
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Endocrine Cancer; Paragangliomas 1, with or without deafness, 168000; Pheochromocytoma, 171300; Carcinoid tumors, intestinal, 114900; Merkel cell carcinoma, somatic; Paraganglioma and gastric stromal sarcoma, 606864; Cowden syndrome 3, 615106
Tag for-review was removed from gene: TP53.
Gene: tp53 has been classified as Amber List (Moderate Evidence).
gene: TP53 was added gene: TP53 was added to Endocrine neoplasms. Sources: Expert Review for-review tags were added to gene: TP53. Mode of inheritance for gene: TP53 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Phenotypes for gene: TP53 were set to Endocrine Cancer; Paragangliomas 1, with or without deafness, 168000; Pheochromocytoma, 171300; Carcinoid tumors, intestinal, 114900; Merkel cell carcinoma, somatic; Paraganglioma and gastric stromal sarcoma, 606864; Cowden syndrome 3, 615106 Review for gene: TP53 was set to AMBER