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  2. Hypogonadotropic hypogonadism (GMS)
  3. ANOS1
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Hypogonadotropic hypogonadism (GMS)

Gene: ANOS1

Green List (high evidence)
ANOS1 (anosmin 1)
EnsemblGeneIds (GRCh38): ENSG00000011201
EnsemblGeneIds (GRCh37): ENSG00000011201
OMIM: 300836, Gene2Phenotype
ANOS1 is in 7 panels

3 reviews

Ivone Leong (Genomics England Curator)

Comment on mode of inheritance: MOI was corrected.
Created: 5 Nov 2019, 11:39 a.m. | Last Modified: 5 Nov 2019, 11:39 a.m.
Panel Version: 1.1
Created: 5 Nov 2019, 11:39 a.m.
Last Modified: 5 Nov 2019, 11:39 a.m.
Panel version: 1.1

Simon Thomas (Wessex Regional Genetics Laboratory)

Green List (high evidence)

Created: 22 Mar 2019, 5:03 p.m.

Panel version: 0.7

Martina Owens (Exeter Genetics Laboratory, Royal Devon and Exeter NHS Foundation Trust)

Green List (high evidence)

Created: 15 Mar 2019, 11:15 a.m.

Panel version: 0.5

Details

Mode of Inheritance
X-LINKED: hemizygous mutation in males, biallelic mutations in females
Sources
  • Expert Review Green
  • Wessex and West Midlands GLH
  • NHS GMS
  • South West GLH
Phenotypes
  • Hypogonadotropic hypogonadism type 1 (OMIM 308700)
OMIM
300836
Clinvar variants
Variants in ANOS1
Penetrance
None
Panels with this gene

History Filter Activity

5 Nov 2019, Gel status: 3

Set mode of inheritance

Ivone Leong (Genomics England Curator)

Mode of inheritance for gene: ANOS1 was changed from BIALLELIC, autosomal or pseudoautosomal to X-LINKED: hemizygous mutation in males, biallelic mutations in females

22 Mar 2019, Gel status: 3

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: anos1 has been classified as Green List (High Evidence).

22 Mar 2019, Gel status: 1

Added New Source

Ivone Leong (Genomics England Curator)

Source Wessex and West Midlands GLH was added to ANOS1.

15 Mar 2019, Gel status: 1

Set Phenotypes

Ivone Leong (Genomics England Curator)

Added phenotypes Hypogonadotropic hypogonadism type 1 (OMIM 308700) for gene: ANOS1

15 Mar 2019, Gel status: 1

Created, Added New Source, Set mode of inheritance

Ivone Leong (Genomics England Curator)

gene: ANOS1 was added gene: ANOS1 was added to Hypogonadotropic hypogonadism idiopathic. Sources: South West GLH,NHS GMS Mode of inheritance for gene: ANOS1 was set to BIALLELIC, autosomal or pseudoautosomal