Thoracic aortic aneurysm or dissection (GMS)

Gene: PRKG1

Green List (high evidence)

Submitted on behalf of the GMS Cardiology specialist group. The group has agreed that this gene should be Green on this panel. Therefore this gene has been promoted from Amber to Green

Created: 18 Nov 2019, 4:33 p.m. | Last Modified: 18 Nov 2019, 4:33 p.m.

Panel Version: 0.35

Green List (high evidence)

Literature consistently associates gene with familial TAAD.

Created: 2 Oct 2019, 11:24 a.m. | Last Modified: 2 Oct 2019, 11:24 a.m.

Panel Version: 0.30

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
Aortic aneurysm, familial thoracic 8 615436

Publications

• 23910461
• 30577811

On CGGL Royal Brompton FTAAD panel. Pathogenic variants (same as recurrent reported one) reported in referrals for aortic aneurysm.

Created: 18 Sep 2019, 8:43 p.m. | Last Modified: 18 Sep 2019, 8:43 p.m.

Panel Version: 0.30

Phenotypes
OMIM 615436 Aortic aneurysm, familial thoracic 8

Publications

• 23910461
• 27442293

Variants in this GENE are reported as part of current diagnostic practice

Green List (high evidence)

615436 FTAAD non-syndromic

Created: 25 Mar 2019, 4:30 p.m.

Two disease-causing variants reported to HGMD, both published by Overwater et al 2018 Hum Mutat 39:1143 PMID:29907982 one missense variant and one in-frame deletion of exon 3. No segregation for either variant, but the missense variant c.530G>A p.(Arg177Gln) has been reported elsewhere (Guo et al 2013 Am J Hum Genet 93:398 PMID:23910461) with segregation in 18 affected members of 4 families. Other variants are reported as ?DM on HGMD.

Created: 25 Mar 2019, 4:27 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Variants in this GENE are reported as part of current diagnostic practice

Green List (high evidence)

I don't know

This gene was part of an initial gene list collated by Matthew Edwards Royal Brompton Hospital sent 16th Jan 2019 on behalf of the London South GLH for review by the GMS Cardiology Specialist Group. Only gene symbol from the Royal Brompton gene panel was provided - suggested initial gene rating and evidence for inclusion not provided with the list.

Created: 20 Feb 2019, 2:17 p.m.

Not on the Inherited Cardiac Condition Genes panel for Familial aortic anuerysm reported in: Development of a Comprehensive Sequencing Assay for Inherited Cardiac Condition Genes, Pua et al, Journal of Cardiovascular Translational Research, online Feb 2016 (doi:10.​1007/​s12265-016-9673-5). The panel contains disease-causing, putatively pathogenic, research and phenocopy genes.

Created: 19 Feb 2016, 10:58 a.m.

Green List (high evidence)

Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections. Am. J. Hum. Genet. 93: 398-404, 2013. (PubMed: 23910461)

Created: 14 Feb 2016, 12:29 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
615436- Aortic aneurysm, familial thoracic 8

Publications

• PubMed: 23910461

Mode of pathogenicity
Other