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Cardiomyopathies - including childhood onset

Gene: KRAS

Green List (high evidence)

KRAS (KRAS proto-oncogene, GTPase)
EnsemblGeneIds (GRCh38): ENSG00000133703
EnsemblGeneIds (GRCh37): ENSG00000133703
OMIM: 190070, Gene2Phenotype
KRAS is in 30 panels

4 reviews

Ivone Leong (Genomics England Curator)

Green List (high evidence)

Submitted on behalf of the GMS Cardiology specialist group. The group has agreed that this gene should be Green on this panel.
Created: 2 Dec 2019, 3:58 p.m. | Last Modified: 2 Dec 2019, 3:58 p.m.
Panel Version: 0.16

Rebecca Whittington (South West GLH)

I don't know

Cardiofaciocutaneous syndrome 2 OMIM#615278; Noonan syndrome 3 OMIM#609942 AD 3 RAS-associated autoimmune leukoproliferative disorder OMIM#614470 includes also a number of somatic cancers.
Created: 25 Mar 2019, 4:30 p.m.
Not listed with cardiomyopathies. Through OMIM clinical synopsis - HCM occurs but many other cardiac features including CHD. Not a major feature . HGMD has many phenotypes associated including a variety of cancers. Rasopathy gene - childhood onset and denovo variants reported Stark Clin Genet. 2012 Jun;81(6):590-4.
Created: 25 Mar 2019, 4:27 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Variants in this GENE are reported as part of current diagnostic practice

Ellen McDonagh (Genomics England Curator)

Comment on mode of pathogenicity: Actvating mutation consequence from G2P. Comments from Reviewer: <5% of cases of CFC are caused by activating mutations in KRAS. activating mutations in the gene are also known to cause <5% of cases of Noonan syndrome. - Helen Savage (Congenica Ltd), Jan. 21, 2016, 10:28 a.m. Gain of function mutations in KRAS cause Noonan syndrome and Cardio-Facio-cutanenous syndrome. This disorders share phenotypes with Legius syndrome. No reports of mutations in KRAS causing Legius syndrome. - Helen Savage (Congenica Ltd), Jan. 25, 2016, 11:43 a.m. Gain of function mutations in KRAS are found in up to 5% of patients with Noonan syndrome and up to 5% of patients with CFC. - Helen Savage (Congenica Ltd), Jan. 21, 2016, 1:26 p.m.
Created: 5 Feb 2016, 12:14 p.m.
Comment on mode of inheritance: Monoallelic confirmed in G2P, and not on imprinted gene list.
Created: 4 Feb 2016, 3:56 p.m.

Helen Savage (Congenica Ltd)

Green List (high evidence)

Gain of function mutations
Created: 1 Feb 2016, 10:43 a.m.

Phenotypes
Noonan syndrome; Cardio-Facio-cutanenous syndrome

Mode of pathogenicity
Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • NHS GMS
  • Expert List
  • South West GLH
  • London South GLH
  • Expert Review Green
Phenotypes
  • Noonan syndrome 3
  • Noonan syndrome
  • CFC syndrome
  • Cardiofaciocutaneous syndrome 2 615278
  • Noonan syndrome 3 609942
  • Cardiofaciocutaneous syndrome 2
  • Cardiofaciocutaneous Syndrome
  • Cardio-Facio-Cutaneous syndrome
OMIM
190070
Clinvar variants
Variants in KRAS
Penetrance
None
Publications
Mode of Pathogenicity
Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments
Panels with this gene

History Filter Activity

2 Dec 2019, Gel status: 3

Added New Source

Ivone Leong (Genomics England Curator)

Source NHS GMS was added to KRAS.

4 Sep 2019, Gel status: 3

Added New Source, Set mode of pathogenicity, Set Phenotypes

Ivone Leong (Genomics England Curator)

Source Expert List was added to KRAS. Mode of pathogenicity for gene KRAS was changed from to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments Added phenotypes Cardiofaciocutaneous syndrome 2 615278; Noonan syndrome 3 609942 for gene: KRAS

4 Sep 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ivone Leong (Genomics England Curator)

gene: KRAS was added gene: KRAS was added to Cardiomyopathies - including childhood onset. Sources: Expert Review Green,London South GLH,South West GLH Mode of inheritance for gene: KRAS was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: KRAS were set to PMID: 21396583 Phenotypes for gene: KRAS were set to Noonan syndrome; Cardio-Facio-Cutaneous syndrome; CFC syndrome; Cardiofaciocutaneous syndrome 2; Cardiofaciocutaneous Syndrome; Noonan syndrome 3