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Cardiomyopathies - including childhood onset

Gene: TMPO

Red List (low evidence)

TMPO (thymopoietin)
EnsemblGeneIds (GRCh38): ENSG00000120802
EnsemblGeneIds (GRCh37): ENSG00000120802
OMIM: 188380, Gene2Phenotype
TMPO is in 5 panels

2 reviews

Ivone Leong (Genomics England Curator)

Red List (low evidence)

Submitted on behalf of the GMS Cardiology specialist group. The group has agreed that this gene should be Red on this panel.
Created: 2 Dec 2019, 3:58 p.m. | Last Modified: 2 Dec 2019, 3:58 p.m.
Panel Version: 0.16

Rebecca Whittington (South West GLH)

Red List (low evidence)

No phenotype on OMIM
Created: 25 Mar 2019, 4:30 p.m.
Taylor 2005 Hum Mutat 26(6), 566574, 2005.1 variant but high freq and adult onset.
Created: 25 Mar 2019, 4:27 p.m.

Variants in this GENE are reported as part of current diagnostic practice

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • NHS GMS
  • South West GLH
  • Expert Review Red
Phenotypes
  • Dilated Cardiomyopathy, Dominant
OMIM
188380
Clinvar variants
Variants in TMPO
Penetrance
None
Panels with this gene

History Filter Activity

2 Dec 2019, Gel status: 1

Added New Source

Ivone Leong (Genomics England Curator)

Source NHS GMS was added to TMPO.

4 Sep 2019, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Ivone Leong (Genomics England Curator)

gene: TMPO was added gene: TMPO was added to Cardiomyopathies - including childhood onset. Sources: Expert Review Red,South West GLH Mode of inheritance for gene: TMPO was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Phenotypes for gene: TMPO were set to Dilated Cardiomyopathy, Dominant