Cardiomyopathies - including childhood onsetGene: LAMA4
Submitted on behalf of the GMS Cardiology specialist group. The group has agreed that this gene should be Red on this panel.
Created: 2 Dec 2019, 3:58 p.m. | Last Modified: 2 Dec 2019, 3:58 p.m.
Panel Version: 0.16
Cardiomyopathy, dilated, 1JJ OMIM#615235
Created: 25 Mar 2019, 4:30 p.m.
HGMD: 5 DM variants on HGMD assoc with HCM (Bottillo (2016) Gene 577: 227 PubMed: 26656175) and DCM -Marston (2015) PLoS One 10: e0138568 PubMed: 26406308. Appears to be adult onset and not a lot of evidence of pathogenic variants.
Created: 25 Mar 2019, 4:27 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Variants in this GENE are reported as part of current diagnostic practice
Source NHS GMS was added to LAMA4.
gene: LAMA4 was added gene: LAMA4 was added to Cardiomyopathies - including childhood onset. Sources: Expert Review Red,South West GLH Mode of inheritance for gene: LAMA4 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted