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  2. Sudden cardiac death - previous panel
  3. TMPO
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Sudden cardiac death - previous panel

Gene: TMPO

Red List (low evidence)
TMPO (thymopoietin)
EnsemblGeneIds (GRCh38): ENSG00000120802
EnsemblGeneIds (GRCh37): ENSG00000120802
OMIM: 188380, Gene2Phenotype
TMPO is in 3 panels

2 reviews

Ellen McDonagh (Genomics England Curator)

I don't know

This gene was part of an initial gene list collated by Matthew Edwards Royal Brompton Hospital sent 16th Jan 2019 on behalf of the London South GLH for review by the GMS Cardiology Specialist Group. Only gene symbol from the Royal Brompton gene panel was provided - suggested initial gene rating and evidence for inclusion not provided with the list.
Created: 20 Feb 2019, 2:17 p.m.
Created: 20 Feb 2019, 2:17 p.m.

Panel version: Imported from Molecular autopsy panel version 0.86

James Eden (Manchester)

Red List (low evidence)

Gene currently tested on Manchester cardiac gene panel. Only class 1-3 variants detected to date. 13 variants listed on HGMD (accessed 29/01/2019). ClinGen Knowledge Base: refuted association with dilated cardiomyopathy 1T (accessed 29/01/2019).
Created: 14 Feb 2019, 1:38 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
Dilated Cardiomyopathy, Dominant

Publications

Variants in this GENE are reported as part of current diagnostic practice

Created: 14 Feb 2019, 1:38 p.m.

Panel version: Imported from Molecular autopsy panel version 0.82

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • London South GLH
  • North West GLH
  • Expert Review Red
  • London South GLH
  • North West GLH
  • Expert Review Red
Phenotypes
  • Dilated Cardiomyopathy, Dominant
OMIM
188380
Clinvar variants
Variants in TMPO
Penetrance
None
Publications
Panels with this gene

History Filter Activity

9 Sep 2019, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ivone Leong (Genomics England Curator)

gene: TMPO was added gene: TMPO was added to Sudden cardiac death. Sources: Expert Review Red,North West GLH,London South GLH Mode of inheritance for gene: TMPO was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Publications for gene: TMPO were set to 16247757 Phenotypes for gene: TMPO were set to Dilated Cardiomyopathy, Dominant