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Familial Meniere Disease v1.3 TNFRSF1A Arina Puzriakova Phenotypes for gene: TNFRSF1A were changed from to Periodic fever, familial, OMIM:142680
Familial Meniere Disease v1.2 CACNA1A Arina Puzriakova Phenotypes for gene: CACNA1A were changed from Episodic ataxia type 2; migraine familial hemiplegic type 1 to Episodic ataxia, type 2, OMIM:108500; Migraine, familial hemiplegic, 1, OMIM:141500; Migraine, familial hemiplegic, 1, with progressive cerebellar ataxia, OMIM:141500
Familial Meniere Disease v1.1 AQP6 Eldar Dedic reviewed gene: AQP6: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: Unknown
Familial Meniere Disease v1.1 AQP5 Eldar Dedic reviewed gene: AQP5: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: Unknown
Familial Meniere Disease v1.1 AQP3 Eldar Dedic reviewed gene: AQP3: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: Unknown
Familial Meniere Disease v1.1 AQP2 Eldar Dedic reviewed gene: AQP2: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: Unknown
Familial Meniere Disease v1.1 AQP1 Eldar Dedic reviewed gene: AQP1: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: Unknown
Familial Meniere Disease v1.1 ADD3 Eldar Dedic reviewed gene: ADD3: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: Unknown
Familial Meniere Disease v1.1 ADD2 Eldar Dedic reviewed gene: ADD2: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: Unknown
Familial Meniere Disease v1.1 ADD1 Eleanor Williams changed review comment from: As noted by the expert reviewer Eldar Dedic, PMID: 30828346 - Gallego-Martinez, et al. (2019) reports a family in which two members have a rare variant of unknown signficance in ADD1 (chr4:2900221 A>G). In addition, two other rare variants in candidate genes are reported in 2 family members (KCNQ4) and in all cases within the famile (DPT). See Table 5, family 2.

This adds some weight to ADD1 being associated with Familial Meniere disease, and so the watchlist tag has been added to this gene.; to: As noted by the expert reviewer Eldar Dedic, PMID: 30828346 - Gallego-Martinez, et al. (2019) reports a family in which two members have a rare missense variant of unknown signficance in ADD1 (chr4:2900221 A>G (grch37, rs372777117). In addition, two other rare variants in candidate genes are reported in 2 members of the same family (variant in KCNQ4) and in all cases within the family (variant in DPT). See Table 5, family 2.

This adds some weight to ADD1 being associated with Familial Meniere disease, and so the watchlist tag has been added to this gene.
Familial Meniere Disease v1.1 ADD1 Eleanor Williams reviewed gene: ADD1: Rating: ; Mode of pathogenicity: None; Publications: 30828346; Phenotypes: ; Mode of inheritance: None
Familial Meniere Disease v1.1 ADD1 Eleanor Williams Tag watchlist tag was added to gene: ADD1.
Familial Meniere Disease v1.1 ADD1 Eldar Dedic reviewed gene: ADD1: Rating: RED; Mode of pathogenicity: None; Publications: PMID:30828346; Phenotypes: ; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Familial Meniere Disease v1.1 COCH Eleanor Williams commented on gene: COCH: Several cases of biallelic variants reported in families with hearing loss (see https://panelapp.genomicsengland.co.uk/panels/126/gene/COCH/) but none report Meniere disease combination of phenotype so leaving the mode of inheritance as monoallelic on the Familial Meniere Disease panel.
Familial Meniere Disease Eleanor Williams promoted panel to version 1.0
Familial Meniere Disease WFS1 Eleanor Williams edited their review of WFS1
Familial Meniere Disease WFS1 Eleanor Williams classified WFS1 as Red List (low evidence)
Familial Meniere Disease MARVELD2 Eleanor Williams marked MARVELD2 as ready
Familial Meniere Disease MARVELD2 Eleanor Williams classified MARVELD2 as Red List (low evidence)
Familial Meniere Disease PTPN22 Eleanor Williams marked PTPN22 as ready
Familial Meniere Disease PRKCB Eleanor Williams marked PRKCB as ready
Familial Meniere Disease PRKCB Eleanor Williams edited their review of PRKCB
Familial Meniere Disease PRKCB Eleanor Williams classified PRKCB as Amber List (moderate evidence)
Familial Meniere Disease NFKB1 Eleanor Williams marked NFKB1 as ready
Familial Meniere Disease NFKB1 Eleanor Williams classified NFKB1 as Red List (low evidence)
Familial Meniere Disease HLA-DRB1 Eleanor Williams marked HLA-DRB1 as ready
Familial Meniere Disease HLA-DRB1 Eleanor Williams classified HLA-DRB1 as Red List (low evidence)
Familial Meniere Disease FAM136A Eleanor Williams marked FAM136A as ready
Familial Meniere Disease FAM136A Eleanor Williams classified FAM136A as Amber List (moderate evidence)
Familial Meniere Disease FAM136A Eleanor Williams edited their review of FAM136A
Familial Meniere Disease DTNA Eleanor Williams marked DTNA as ready
Familial Meniere Disease DTNA Eleanor Williams classified DTNA as Amber List (moderate evidence)
Familial Meniere Disease DTNA Eleanor Williams edited their review of DTNA
Familial Meniere Disease DPT Eleanor Williams marked DPT as ready
Familial Meniere Disease DPT Eleanor Williams classified DPT as Amber List (moderate evidence)
Familial Meniere Disease DIAPH1 Eleanor Williams marked DIAPH1 as ready
Familial Meniere Disease CACNA1A Eleanor Williams marked CACNA1A as ready
Familial Meniere Disease AQP4 Eleanor Williams marked AQP4 as ready
Familial Meniere Disease AQP4 Eleanor Williams classified AQP4 as Red List (low evidence)
Familial Meniere Disease COCH Eleanor Williams marked COCH as ready
Familial Meniere Disease WFS1 Jose Antonio Lopez-Escamez reviewed WFS1
Familial Meniere Disease MARVELD2 Jose Antonio Lopez-Escamez Added gene to panel
Familial Meniere Disease PTPN22 Jose Antonio Lopez-Escamez commented on PTPN22
Familial Meniere Disease NFKB1 Jose Antonio Lopez-Escamez reviewed NFKB1
Familial Meniere Disease HLA-DRB1 Jose Antonio Lopez-Escamez reviewed HLA-DRB1
Familial Meniere Disease DTNA Jose Antonio Lopez-Escamez reviewed DTNA
Familial Meniere Disease FAM136A Jose Antonio Lopez-Escamez reviewed FAM136A
Familial Meniere Disease PRKCB Jose Antonio Lopez-Escamez reviewed PRKCB
Familial Meniere Disease DPT Jose Antonio Lopez-Escamez reviewed DPT
Familial Meniere Disease AQP4 Jose Antonio Lopez-Escamez reviewed AQP4
Familial Meniere Disease COCH Jose Antonio Lopez-Escamez reviewed COCH
Familial Meniere Disease CACNA1A Georgios Korres reviewed CACNA1A
Familial Meniere Disease COCH Eleanor Williams edited their review of COCH
Familial Meniere Disease COCH Eleanor Williams commented on COCH
Familial Meniere Disease PRKCB Eleanor Williams edited their review of PRKCB
Familial Meniere Disease FAM136A Eleanor Williams edited their review of FAM136A
Familial Meniere Disease COCH Eleanor Williams commented on COCH
Familial Meniere Disease COCH Eleanor Williams edited their review of COCH
Familial Meniere Disease DTNA Eleanor Williams commented on DTNA
Familial Meniere Disease COCH Ellen McDonagh marked COCH as ready
Familial Meniere Disease COCH Georgios Korres reviewed COCH
Familial Meniere Disease PRKCB Georgios Korres reviewed PRKCB
Familial Meniere Disease FAM136A Georgios Korres reviewed FAM136A
Familial Meniere Disease DTNA Georgios Korres reviewed DTNA
Familial Meniere Disease PRKCB Maria Bitner-Glindzicz reviewed PRKCB
Familial Meniere Disease DTNA Maria Bitner-Glindzicz reviewed DTNA
Familial Meniere Disease FAM136A Maria Bitner-Glindzicz reviewed FAM136A
Familial Meniere Disease DIAPH1 Maria Bitner-Glindzicz reviewed DIAPH1
Familial Meniere Disease WFS1 Maria Bitner-Glindzicz reviewed WFS1
Familial Meniere Disease COCH Maria Bitner-Glindzicz reviewed COCH
Familial Meniere Disease CXCL8 Eleanor Williams commented on CXCL8
Familial Meniere Disease WFS1 Eleanor Williams Added gene to panel
Familial Meniere Disease VHL Eleanor Williams Added gene to panel
Familial Meniere Disease VCAM1 Eleanor Williams Added gene to panel
Familial Meniere Disease TNIP1 Eleanor Williams Added gene to panel
Familial Meniere Disease TNFRSF1A Eleanor Williams Added gene to panel
Familial Meniere Disease TNFAIP3 Eleanor Williams Added gene to panel
Familial Meniere Disease TNF Eleanor Williams Added gene to panel
Familial Meniere Disease TLR9 Eleanor Williams Added gene to panel
Familial Meniere Disease TLR8 Eleanor Williams Added gene to panel
Familial Meniere Disease TLR7 Eleanor Williams Added gene to panel
Familial Meniere Disease TLR4 Eleanor Williams Added gene to panel
Familial Meniere Disease TLR3 Eleanor Williams Added gene to panel
Familial Meniere Disease TLR2 Eleanor Williams Added gene to panel
Familial Meniere Disease TLR10 Eleanor Williams Added gene to panel
Familial Meniere Disease TFB1M Eleanor Williams Added gene to panel
Familial Meniere Disease STAT3 Eleanor Williams Added gene to panel
Familial Meniere Disease SOD2 Eleanor Williams Added gene to panel
Familial Meniere Disease SLC8A1 Eleanor Williams Added gene to panel
Familial Meniere Disease SLC26A4 Eleanor Williams Added gene to panel
Familial Meniere Disease SLC12A2 Eleanor Williams Added gene to panel
Familial Meniere Disease SIK1 Eleanor Williams Added gene to panel
Familial Meniere Disease SEMA3D Eleanor Williams Added gene to panel
Familial Meniere Disease RELA Eleanor Williams Added gene to panel
Familial Meniere Disease REL Eleanor Williams Added gene to panel
Familial Meniere Disease PTPN22 Eleanor Williams Added gene to panel
Familial Meniere Disease PTGS2 Eleanor Williams Added gene to panel
Familial Meniere Disease PRKCB Eleanor Williams Added gene to panel
Familial Meniere Disease POU4F3 Eleanor Williams Added gene to panel
Familial Meniere Disease PON2 Eleanor Williams Added gene to panel
Familial Meniere Disease PON1 Eleanor Williams Added gene to panel
Familial Meniere Disease PARP1 Eleanor Williams Added gene to panel
Familial Meniere Disease NPR3 Eleanor Williams Added gene to panel
Familial Meniere Disease NPR2 Eleanor Williams Added gene to panel
Familial Meniere Disease NPR1 Eleanor Williams Added gene to panel
Familial Meniere Disease NOTCH3 Eleanor Williams Added gene to panel
Familial Meniere Disease NOTCH2 Eleanor Williams Added gene to panel
Familial Meniere Disease NOS3 Eleanor Williams Added gene to panel
Familial Meniere Disease NOS2 Eleanor Williams Added gene to panel
Familial Meniere Disease NFKBIA Eleanor Williams Added gene to panel
Familial Meniere Disease NFKB1 Eleanor Williams Added gene to panel
Familial Meniere Disease NDUFS2 Eleanor Williams Added gene to panel
Familial Meniere Disease NAGA Eleanor Williams Added gene to panel
Familial Meniere Disease MYD88 Eleanor Williams Added gene to panel
Familial Meniere Disease MTRR Eleanor Williams Added gene to panel
Familial Meniere Disease MTR Eleanor Williams Added gene to panel
Familial Meniere Disease MTNR1B Eleanor Williams Added gene to panel
Familial Meniere Disease MTHFR Eleanor Williams Added gene to panel
Familial Meniere Disease MRPS12 Eleanor Williams Added gene to panel
Familial Meniere Disease MMP9 Eleanor Williams Added gene to panel
Familial Meniere Disease MIF Eleanor Williams Added gene to panel
Familial Meniere Disease MICA Eleanor Williams Added gene to panel
Familial Meniere Disease LTF Eleanor Williams Added gene to panel
Familial Meniere Disease KCNQ4 Eleanor Williams Added gene to panel
Familial Meniere Disease KCNQ1 Eleanor Williams Added gene to panel
Familial Meniere Disease KCNE3 Eleanor Williams Added gene to panel
Familial Meniere Disease KCNE1 Eleanor Williams Added gene to panel
Familial Meniere Disease KCNA5 Eleanor Williams Added gene to panel
Familial Meniere Disease KCNA4 Eleanor Williams Added gene to panel
Familial Meniere Disease KCNA1 Eleanor Williams Added gene to panel
Familial Meniere Disease IRF7 Eleanor Williams Added gene to panel
Familial Meniere Disease CXCL8 Eleanor Williams Added gene to panel
Familial Meniere Disease IL6 Eleanor Williams Added gene to panel
Familial Meniere Disease IL2RA Eleanor Williams Added gene to panel
Familial Meniere Disease IL2 Eleanor Williams Added gene to panel
Familial Meniere Disease IL1R1 Eleanor Williams Added gene to panel
Familial Meniere Disease IL1B Eleanor Williams Added gene to panel
Familial Meniere Disease IL1A Eleanor Williams Added gene to panel
Familial Meniere Disease IL18 Eleanor Williams Added gene to panel
Familial Meniere Disease IL10 Eleanor Williams Added gene to panel
Familial Meniere Disease IFNG Eleanor Williams Added gene to panel
Familial Meniere Disease ICAM1 Eleanor Williams Added gene to panel
Familial Meniere Disease HSPA1A Eleanor Williams Added gene to panel
Familial Meniere Disease HLA-DRB5 Eleanor Williams Added gene to panel
Familial Meniere Disease HLA-DRB1 Eleanor Williams Added gene to panel
Familial Meniere Disease HLA-DQA1 Eleanor Williams Added gene to panel
Familial Meniere Disease HLA-DPA2 Eleanor Williams Added gene to panel
Familial Meniere Disease HLA-C Eleanor Williams Added gene to panel
Familial Meniere Disease HLA-B Eleanor Williams Added gene to panel
Familial Meniere Disease HLA-A Eleanor Williams Added gene to panel
Familial Meniere Disease HCFC1 Eleanor Williams Added gene to panel
Familial Meniere Disease GPX5 Eleanor Williams Added gene to panel
Familial Meniere Disease GPX4 Eleanor Williams Added gene to panel
Familial Meniere Disease GPX1 Eleanor Williams Added gene to panel
Familial Meniere Disease GJB6 Eleanor Williams Added gene to panel
Familial Meniere Disease GJB3 Eleanor Williams Added gene to panel
Familial Meniere Disease FOXP3 Eleanor Williams Added gene to panel
Familial Meniere Disease FOS Eleanor Williams Added gene to panel
Familial Meniere Disease FLNA Eleanor Williams Added gene to panel
Familial Meniere Disease FCHO2 Eleanor Williams Added gene to panel
Familial Meniere Disease FCHO1 Eleanor Williams Added gene to panel
Familial Meniere Disease FAM136A Eleanor Williams Added gene to panel
Familial Meniere Disease ESR2 Eleanor Williams Added gene to panel
Familial Meniere Disease ESR1 Eleanor Williams Added gene to panel
Familial Meniere Disease DTNA Eleanor Williams Added gene to panel
Familial Meniere Disease DPT Eleanor Williams Added gene to panel
Familial Meniere Disease DIAPH1 Eleanor Williams Added gene to panel
Familial Meniere Disease DEFB1 Eleanor Williams Added gene to panel
Familial Meniere Disease CXCL9 Eleanor Williams Added gene to panel
Familial Meniere Disease CXCL10 Eleanor Williams Added gene to panel
Familial Meniere Disease CXCL1 Eleanor Williams Added gene to panel
Familial Meniere Disease CTLA4 Eleanor Williams Added gene to panel
Familial Meniere Disease CSF2 Eleanor Williams Added gene to panel
Familial Meniere Disease COCH Eleanor Williams Added gene to panel
Familial Meniere Disease CHGA Eleanor Williams Added gene to panel
Familial Meniere Disease CGA Eleanor Williams Added gene to panel
Familial Meniere Disease CD86 Eleanor Williams Added gene to panel
Familial Meniere Disease CD80 Eleanor Williams Added gene to panel
Familial Meniere Disease CD40 Eleanor Williams Added gene to panel
Familial Meniere Disease CD4 Eleanor Williams Added gene to panel
Familial Meniere Disease CD276 Eleanor Williams Added gene to panel
Familial Meniere Disease CCR5 Eleanor Williams Added gene to panel
Familial Meniere Disease CCND1 Eleanor Williams Added gene to panel
Familial Meniere Disease CCL5 Eleanor Williams Added gene to panel
Familial Meniere Disease CCL4 Eleanor Williams Added gene to panel
Familial Meniere Disease CCL2 Eleanor Williams Added gene to panel
Familial Meniere Disease CAV1 Eleanor Williams Added gene to panel
Familial Meniere Disease CASP3 Eleanor Williams Added gene to panel
Familial Meniere Disease CACNA1A Eleanor Williams Added gene to panel
Familial Meniere Disease AVPR2 Eleanor Williams Added gene to panel
Familial Meniere Disease AR Eleanor Williams Added gene to panel
Familial Meniere Disease AQP6 Eleanor Williams Added gene to panel
Familial Meniere Disease AQP5 Eleanor Williams Added gene to panel
Familial Meniere Disease AQP4 Eleanor Williams Added gene to panel
Familial Meniere Disease AQP3 Eleanor Williams Added gene to panel
Familial Meniere Disease AQP2 Eleanor Williams Added gene to panel
Familial Meniere Disease AQP1 Eleanor Williams Added gene to panel
Familial Meniere Disease ADD3 Eleanor Williams Added gene to panel
Familial Meniere Disease ADD2 Eleanor Williams Added gene to panel
Familial Meniere Disease ADD1 Eleanor Williams Added gene to panel