Activity
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| Inherited pancreatic cancer v3.2 | Arina Puzriakova Panel types changed to GMS Rare Disease Virtual; GMS Rare Disease; GMS signed-off | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v3.1 | Sarah Leigh Panel version 3.0 has been signed off on 2025-04-30 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v3.0 | Sarah Leigh promoted panel to version 3.0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v2.9 | STK11 |
Achchuthan Shanmugasundram Tag Q2_24_promote_green was removed from gene: STK11. Tag Q2_24_NHS_review was removed from gene: STK11. |
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| Inherited pancreatic cancer v2.9 | ATM |
Achchuthan Shanmugasundram Tag Q2_24_promote_green was removed from gene: ATM. Tag Q2_24_MOI was removed from gene: ATM. Tag Q2_24_NHS_review was removed from gene: ATM. |
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| Inherited pancreatic cancer v2.9 | STK11 | Achchuthan Shanmugasundram reviewed gene: STK11: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v2.9 | ATM | Achchuthan Shanmugasundram reviewed gene: ATM: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v2.8 | STK11 |
Achchuthan Shanmugasundram Source Expert Review Green was added to STK11. Rating Changed from Amber List (moderate evidence) to Green List (high evidence) |
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| Inherited pancreatic cancer v2.8 | ATM |
Achchuthan Shanmugasundram Source NHS GMS was added to ATM. Source Expert Review Green was added to ATM. Rating Changed from Amber List (moderate evidence) to Green List (high evidence) |
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| Inherited pancreatic cancer v2.7 | STK11 | Sarah Leigh Phenotypes for gene: STK11 were changed from Pancreatic cancer, somatic, OMIM:260350 to Pancreatic cancer, somatic, OMIM:260350; familial pancreatic carcinoma, MONDO:0015278 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v2.6 | STK11 | Sarah Leigh Publications for gene: STK11 were set to 30558719 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v2.5 | STK11 | Sarah Leigh reviewed gene: STK11: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v2.5 | STK11 |
Sarah Leigh Tag Q2_24_promote_green tag was added to gene: STK11. Tag Q2_24_NHS_review tag was added to gene: STK11. |
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| Inherited pancreatic cancer v2.5 | STK11 | Sarah Leigh Classified gene: STK11 as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v2.5 | STK11 | Sarah Leigh Gene: stk11 has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v2.4 | ATM | Sarah Leigh reviewed gene: ATM: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v2.4 | ATM |
Sarah Leigh Tag Q2_24_promote_green tag was added to gene: ATM. Tag Q2_24_MOI tag was added to gene: ATM. Tag Q2_24_NHS_review tag was added to gene: ATM. |
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| Inherited pancreatic cancer v2.4 | ATM | Sarah Leigh Classified gene: ATM as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v2.4 | ATM | Sarah Leigh Gene: atm has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v2.3 | ATM |
Terri McVeigh gene: ATM was added gene: ATM was added to Inherited pancreatic cancer. Sources: Other Mode of inheritance for gene: ATM was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: ATM were set to 34529012; 33509806 Phenotypes for gene: ATM were set to Breast, prostate, pancreatic cancer predisposition; recessive trait for ataxia telangiectasia Penetrance for gene: ATM were set to Incomplete Mode of pathogenicity for gene: ATM was set to Other Review for gene: ATM was set to GREEN Added comment: Discussed at UKCGG/Cancer Leads meeting 29th February 2024 - consensus that ATM should be added to this panel for diagnostic testing in individuals with pancreatic cancer fulfilling eligibility criteria. Reporting of variants should be restricted to truncating variants, high-risk missense c.7271T/G and exceptional variants as determined by Can-VIG UK, as per other panels where ATM is tested for cancer predisposition (R208/430) Sources: Other |
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| Inherited pancreatic cancer v2.3 | STK11 | Terri McVeigh reviewed gene: STK11: Rating: GREEN; Mode of pathogenicity: None; Publications: 33513864, 11113065, 16707622, 23240097, 23415580; Phenotypes: Peutz-Jeghers syndrome; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v2.1 | Eleanor Williams Panel version 2.0 has been signed off on 2022-11-30 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v2.0 | Eleanor Williams promoted panel to version 2.0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.20 | BRCA1 | Arina Puzriakova edited their review of gene: BRCA1: Added comment: The rating of this gene has been updated following NHS Genomic Medicine Service approval.; Changed rating: GREEN | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.19 | BRCA1 |
Arina Puzriakova Source Expert Review Green was added to BRCA1. Rating Changed from Amber List (moderate evidence) to Green List (high evidence) |
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| Inherited pancreatic cancer v1.18 | CDKN2A | Arina Puzriakova Publications for gene: CDKN2A were set to 30558719 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.17 | STK11 | Arina Puzriakova Phenotypes for gene: STK11 were changed from to Pancreatic cancer, somatic, OMIM:260350 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.16 | RABL3 | Arina Puzriakova Phenotypes for gene: RABL3 were changed from Hereditary pancreatic cancer to {?Pancreatic cancer, susceptibility to, 5}, OMIM:618680; Pancreatic cancer, susceptibility to, 5, MONDO:0032867 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.15 | PRSS1 | Arina Puzriakova Added comment: Comment on phenotypes: This gene is also associated with Pancreatitis, hereditary (MIM#167800) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.15 | PRSS1 | Arina Puzriakova Phenotypes for gene: PRSS1 were changed from to Malignant pancreatic neoplasm, MONDO:0009831 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.14 | PMS2 | Arina Puzriakova Added comment: Comment on phenotypes: This gene is also associated with Colorectal cancer, hereditary nonpolyposis, type 4 (MIM# 614337); Mismatch repair cancer syndrome 4 (MIM# 619101) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.14 | PMS2 | Arina Puzriakova Phenotypes for gene: PMS2 were changed from to Malignant pancreatic neoplasm, MONDO:0009831 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.13 | MSH6 | Arina Puzriakova Added comment: Comment on phenotypes: This gene is also associated with {Endometrial cancer, familial} (MIM# 608089); Colorectal cancer, hereditary nonpolyposis, type 5 (MIM# 614350); Mismatch repair cancer syndrome 2 (MIM# 619097) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.13 | MSH6 | Arina Puzriakova Phenotypes for gene: MSH6 were changed from to Malignant pancreatic neoplasm, MONDO:0009831 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.12 | MSH2 | Arina Puzriakova Added comment: Comment on phenotypes: This gene is also associated with Colorectal cancer, hereditary nonpolyposis, type 1 (MIM# 120435); Mismatch repair cancer syndrome 2 (MIM# 619096); Muir-Torre syndrome (MIM# 158320) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.12 | MSH2 | Arina Puzriakova Phenotypes for gene: MSH2 were changed from to Malignant pancreatic neoplasm, MONDO:0009831 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.11 | MLH1 | Arina Puzriakova Added comment: Comment on phenotypes: Comment on phenotypes: This gene is also associated with Colorectal cancer, hereditary nonpolyposis, type 2 (MIM# 609310); Mismatch repair cancer syndrome 1 (MIM# 276300); Muir-Torre syndrome (MIM# 158320) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.11 | MLH1 | Arina Puzriakova Phenotypes for gene: MLH1 were changed from to Malignant pancreatic neoplasm, MONDO:0009831 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.10 | CDK4 | Arina Puzriakova Added comment: Comment on phenotypes: This gene is also associated with {Melanoma, cutaneous malignant, 3} (MIM# 609048) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.10 | CDK4 | Arina Puzriakova Phenotypes for gene: CDK4 were changed from to Malignant pancreatic neoplasm, MONDO:0009831 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.9 | CDK4 | Arina Puzriakova Mode of pathogenicity for gene: CDK4 was changed from to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.8 | BRCA1 | Arina Puzriakova Added comment: Comment on phenotypes: This gene is also associated with {Breast-ovarian cancer, familial, 1} (MIM# 604370) and Fanconi anemia, complementation group S (MIM# 617883) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.8 | BRCA1 | Arina Puzriakova Phenotypes for gene: BRCA1 were changed from to {Pancreatic cancer, susceptibility to, 4}, OMIM:614320; Pancreatic cancer, susceptibility to, 4, MONDO:0013685 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.7 | PALB2 | Arina Puzriakova Added comment: Comment on phenotypes: This gene is also associated with {Breast cancer, susceptibility to} (MIM# 114480) and Fanconi anemia, complementation group N (MIM# 610832) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.7 | PALB2 | Arina Puzriakova Phenotypes for gene: PALB2 were changed from to {Pancreatic cancer, susceptibility to, 3}, OMIM:613348; Pancreatic cancer, susceptibility to, 3, MONDO:0013236 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.6 | CDKN2A | Arina Puzriakova Added comment: Comment on phenotypes: This gene is also associated with {Melanoma and neural system tumor syndrome} (MIM# 155755) and {Melanoma, cutaneous malignant, 2} (MIM# 155601) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.6 | CDKN2A | Arina Puzriakova Phenotypes for gene: CDKN2A were changed from to {Melanoma-pancreatic cancer syndrome}, OMIM:606719; Melanoma-pancreatic cancer syndrome, MONDO:0011713 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.5 | BRCA2 | Arina Puzriakova Added comment: Comment on phenotypes: This gene is also associated with {Breast-ovarian cancer, familial, 2} (MIM# 612555); {Breast cancer, male, susceptibility to} (MIM# 114480); Prostate cancer (MIM# 176807); Wilms tumor (MIM# 194070); {Medulloblastoma} (MIM# 155255); {Glioblastoma 3} (MIM# 613029); Fanconi anemia, complementation group D1 (MIM# 605724) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.5 | BRCA2 | Arina Puzriakova Phenotypes for gene: BRCA2 were changed from to {Pancreatic cancer 2}, OMIM:613347; Pancreatic cancer, susceptibility to, 2, MONDO:0013235 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.3 | Catherine Snow Panel version has been signed off | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v1.1 | RABL3 |
Ivone Leong gene: RABL3 was added gene: RABL3 was added to Inherited pancreatic cancer. Sources: Literature Mode of inheritance for gene: RABL3 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Publications for gene: RABL3 were set to 31406347 Phenotypes for gene: RABL3 were set to Hereditary pancreatic cancer Review for gene: RABL3 was set to AMBER Added comment: PMID: 31406347 describes a family with heterozygous variant in the RABL3 gene that causes a premature nonsense mutation. The family has multiple cases of pancreatic ductal adenocarcinoma. Sanger sequencing of the affected family showed significant co-segregation of the variant with cancer. Heterozygous knockdown of the rabl3 gene in zebrafish show increased susceptibility to cancer formation. Sources: Literature |
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| Inherited pancreatic cancer v1.0 | Rebecca Foulger promoted panel to version 1.0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.42 | STK11 | Rebecca Foulger Publications for gene: STK11 were set to | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.41 | PRSS1 | Rebecca Foulger Publications for gene: PRSS1 were set to | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.40 | PMS2 | Rebecca Foulger Publications for gene: PMS2 were set to | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.39 | MSH6 | Rebecca Foulger Publications for gene: MSH6 were set to | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.38 | MSH2 | Rebecca Foulger Publications for gene: MSH2 were set to | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.37 | MLH1 | Rebecca Foulger Publications for gene: MLH1 were set to | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.36 | CDK4 | Rebecca Foulger Publications for gene: CDK4 were set to | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.35 | BRCA1 | Rebecca Foulger Publications for gene: BRCA1 were set to | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.34 | PALB2 | Rebecca Foulger Publications for gene: PALB2 were set to | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.33 | CDKN2A | Rebecca Foulger Publications for gene: CDKN2A were set to | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.32 | BRCA2 | Rebecca Foulger Publications for gene: BRCA2 were set to | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.31 | Rebecca Foulger Panel types changed to GMS Rare Disease; GMS signed-off | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.29 | Ivone Leong List of related panels changed from to R367 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.28 | STK11 | Ivone Leong Classified gene: STK11 as Red List (low evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.28 | STK11 | Ivone Leong Added comment: Comment on list classification: As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that this gene should be rated red. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.28 | STK11 | Ivone Leong Gene: stk11 has been classified as Red List (Low Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.27 | CDK4 | Ivone Leong Classified gene: CDK4 as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.27 | CDK4 | Ivone Leong Added comment: Comment on list classification: As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that this gene should be rated amber. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.27 | CDK4 | Ivone Leong Gene: cdk4 has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.26 | PRSS1 | Anna de Burca Classified gene: PRSS1 as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.26 | PRSS1 | Anna de Burca Gene: prss1 has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.25 | PRSS1 | Ivone Leong Mode of inheritance for gene: PRSS1 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.24 | PMS2 | Ivone Leong Mode of inheritance for gene: PMS2 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.23 | MSH6 | Ivone Leong Mode of inheritance for gene: MSH6 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.22 | MSH2 | Ivone Leong Mode of inheritance for gene: MSH2 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.21 | MLH1 | Ivone Leong Mode of inheritance for gene: MLH1 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.20 | BRCA1 | Ivone Leong Mode of inheritance for gene: BRCA1 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.19 | STK11 | Ivone Leong Mode of inheritance for gene: STK11 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.18 | PALB2 | Ivone Leong Mode of inheritance for gene: PALB2 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.17 | CDKN2A | Ivone Leong Mode of inheritance for gene: CDKN2A was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.16 | CDK4 | Ivone Leong Mode of inheritance for gene: CDK4 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.15 | BRCA2 | Ivone Leong Mode of inheritance for gene: BRCA2 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.13 | STK11 | Ivone Leong Classified gene: STK11 as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.13 | STK11 | Ivone Leong Gene: stk11 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.12 | PMS2 | Ivone Leong Classified gene: PMS2 as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.12 | PMS2 | Ivone Leong Gene: pms2 has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.11 | PALB2 | Ivone Leong Classified gene: PALB2 as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.11 | PALB2 | Ivone Leong Gene: palb2 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.10 | MSH6 | Ivone Leong Classified gene: MSH6 as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.10 | MSH6 | Ivone Leong Gene: msh6 has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.9 | MSH2 | Ivone Leong Classified gene: MSH2 as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.9 | MSH2 | Ivone Leong Gene: msh2 has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.8 | MLH1 | Ivone Leong Classified gene: MLH1 as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.8 | MLH1 | Ivone Leong Gene: mlh1 has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.7 | CDKN2A | Ivone Leong Classified gene: CDKN2A as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.7 | CDKN2A | Ivone Leong Gene: cdkn2a has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.6 | CDK4 | Ivone Leong Classified gene: CDK4 as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.6 | CDK4 | Ivone Leong Gene: cdk4 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.5 | BRCA2 | Ivone Leong Classified gene: BRCA2 as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.5 | BRCA2 | Ivone Leong Gene: brca2 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.4 | BRCA1 | Ivone Leong Classified gene: BRCA1 as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.4 | BRCA1 | Ivone Leong Gene: brca1 has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.3 | PMS2 | Rachel Robinson reviewed gene: PMS2: Rating: AMBER; Mode of pathogenicity: ; Publications: 30558719; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.3 | MSH6 | Rachel Robinson reviewed gene: MSH6: Rating: AMBER; Mode of pathogenicity: ; Publications: 30558719; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.3 | MSH2 | Rachel Robinson reviewed gene: MSH2: Rating: AMBER; Mode of pathogenicity: ; Publications: 30558719; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.3 | MLH1 | Rachel Robinson reviewed gene: MLH1: Rating: AMBER; Mode of pathogenicity: ; Publications: 30558719; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.3 | PRSS1 | Rachel Robinson reviewed gene: PRSS1: Rating: AMBER; Mode of pathogenicity: ; Publications: 30558719; Phenotypes: ; Mode of inheritance: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.3 | BRCA1 | Rachel Robinson reviewed gene: BRCA1: Rating: AMBER; Mode of pathogenicity: ; Publications: 30558719; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.3 | STK11 | Rachel Robinson reviewed gene: STK11: Rating: GREEN; Mode of pathogenicity: ; Publications: 30558719; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.3 | PALB2 | Rachel Robinson reviewed gene: PALB2: Rating: GREEN; Mode of pathogenicity: ; Publications: 30558719; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.3 | CDKN2A | Rachel Robinson reviewed gene: CDKN2A: Rating: GREEN; Mode of pathogenicity: ; Publications: 30558719; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.3 | CDK4 | Rachel Robinson reviewed gene: CDK4: Rating: GREEN; Mode of pathogenicity: ; Publications: 30558719; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.3 | BRCA2 | Rachel Robinson reviewed gene: BRCA2: Rating: GREEN; Mode of pathogenicity: ; Publications: 30558719; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.3 | PMS2 | Lara Hawkes reviewed gene: PMS2: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.3 | MSH6 | Lara Hawkes reviewed gene: MSH6: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.3 | MSH2 | Lara Hawkes reviewed gene: MSH2: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.3 | MLH1 | Lara Hawkes reviewed gene: MLH1: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.3 | PRSS1 | Lara Hawkes reviewed gene: PRSS1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.3 | PALB2 | Lara Hawkes reviewed gene: PALB2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.3 | CDKN2A | Lara Hawkes reviewed gene: CDKN2A: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.3 | BRCA2 | Lara Hawkes reviewed gene: BRCA2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v0.2 | BRCA1 |
Ivone Leong gene: BRCA1 was added gene: BRCA1 was added to Inherited pancreatic cancer. Sources: NHS GMS Mode of inheritance for gene: BRCA1 was set to |
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| Inherited pancreatic cancer v0.2 | STK11 |
Ivone Leong gene: STK11 was added gene: STK11 was added to Inherited pancreatic cancer. Sources: NHS GMS Mode of inheritance for gene: STK11 was set to |
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| Inherited pancreatic cancer v0.2 | CDK4 |
Ivone Leong gene: CDK4 was added gene: CDK4 was added to Inherited pancreatic cancer. Sources: NHS GMS Mode of inheritance for gene: CDK4 was set to |
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| Inherited pancreatic cancer v0.2 | PMS2 |
Ivone Leong gene: PMS2 was added gene: PMS2 was added to Inherited pancreatic cancer. Sources: Expert List,NHS GMS Mode of inheritance for gene: PMS2 was set to |
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| Inherited pancreatic cancer v0.2 | MSH6 |
Ivone Leong gene: MSH6 was added gene: MSH6 was added to Inherited pancreatic cancer. Sources: Expert List,NHS GMS Mode of inheritance for gene: MSH6 was set to |
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| Inherited pancreatic cancer v0.2 | MSH2 |
Ivone Leong gene: MSH2 was added gene: MSH2 was added to Inherited pancreatic cancer. Sources: Expert List,NHS GMS Mode of inheritance for gene: MSH2 was set to |
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| Inherited pancreatic cancer v0.2 | MLH1 |
Ivone Leong gene: MLH1 was added gene: MLH1 was added to Inherited pancreatic cancer. Sources: Expert List,NHS GMS Mode of inheritance for gene: MLH1 was set to |
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| Inherited pancreatic cancer v0.2 | PRSS1 |
Ivone Leong gene: PRSS1 was added gene: PRSS1 was added to Inherited pancreatic cancer. Sources: Expert List,NHS GMS Mode of inheritance for gene: PRSS1 was set to |
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| Inherited pancreatic cancer v0.2 | PALB2 |
Ivone Leong gene: PALB2 was added gene: PALB2 was added to Inherited pancreatic cancer. Sources: Expert List,NHS GMS Mode of inheritance for gene: PALB2 was set to |
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| Inherited pancreatic cancer v0.2 | CDKN2A |
Ivone Leong gene: CDKN2A was added gene: CDKN2A was added to Inherited pancreatic cancer. Sources: Expert List,NHS GMS Mode of inheritance for gene: CDKN2A was set to |
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| Inherited pancreatic cancer v0.2 | BRCA2 |
Ivone Leong gene: BRCA2 was added gene: BRCA2 was added to Inherited pancreatic cancer. Sources: Expert List,NHS GMS Mode of inheritance for gene: BRCA2 was set to |
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| Inherited pancreatic cancer v0.0 |
Ellen McDonagh Added Panel Inherited pancreatic cancer Set panel types to: GMS Rare Disease |
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