Proteinuric renal disease
Gene: STS
STS (steroid sulfatase)
EnsemblGeneIds (GRCh38): ENSG00000101846
EnsemblGeneIds (GRCh37): ENSG00000101846
OMIM: 300747, Gene2Phenotype
STS is in 11 panels
EnsemblGeneIds (GRCh38): ENSG00000101846
EnsemblGeneIds (GRCh37): ENSG00000101846
OMIM: 300747, Gene2Phenotype
STS is in 11 panels
1 review
John Sayer (Newcastle University)
Good evidence this is a proteinuric gene. Cases of whole gene deletion of STS in Genomics England with phenotypes.
Sources: Expert listCreated: 22 May 2026, 11:49 a.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Proteinuria; ichthyosis
Publications
Details
- Mode of Inheritance
- BIALLELIC, autosomal or pseudoautosomal
- Sources
-
- Phenotypes
-
- Proteinuria
- ichthyosis
- OMIM
- 300747
- Clinvar variants
- Variants in STS
- Penetrance
- Complete
- Publications
- Panels with this gene
-
- Corneal dystrophy
- Autosomal recessive congenital ichthyosis
- Proteinuric renal disease
- Ichthyosis and erythrokeratoderma
- Likely inborn error of metabolism
- Palmoplantar keratodermas
- Intellectual disability
- DDG2P
- Undiagnosed metabolic disorders
- Childhood onset dystonia, chorea or related movement disorder
- Fetal anomalies
History Filter Activity
22 May 2026, Gel status: 0
Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes, Set penetrance
John Sayer (Newcastle University)gene: STS was added gene: STS was added to Proteinuric renal disease. Sources: Expert list Mode of inheritance for gene: STS was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: STS were set to 22419362; 17468528 Phenotypes for gene: STS were set to Proteinuria; ichthyosis Penetrance for gene: STS were set to Complete Review for gene: STS was set to GREEN