Proteinuric renal disease
Gene: WT1
This gene was part of an initial gene list collated by Elizabeth Watson, North Bristol NHS Trust, February 2019 on behalf of the GMS Renal Specialist Test Group. Gene Symbol submitted: WT1; Suggested initial gene rating: green; Evidence for inclusion: none provided; Other comments: Well reported association with nephrotic syndromeCreated: 4 Feb 2019, 10:41 a.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Denys-Drash syndrome #194080; Frasier syndrome #136680; Wilms tumor, type 1 #194070
Variants in this GENE are reported as part of current diagnostic practice
Pathogenic variants exons 6-9. Multiple hits UK diagnostic panelCreated: 19 Oct 2015, 3:29 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Congenital onset, urogenital anomalies, sex reversal
Publications
Variants in this GENE are reported as part of current diagnostic practice
Phenotypes for gene: WT1 were changed from to Denys-Drash syndrome #194080; Frasier syndrome #136680; Wilms tumor, type 1 #194070
Publications for gene: WT1 were set to
Source NHS GMS was added to WT1. Rating Changed from Green List (high evidence) to Green List (high evidence)
This gene has been classified as Green List (High Evidence).
Mode of inheritance for WT1 was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
This gene has been classified as Green List (High Evidence).
WT1 was added to Proteinuric renal diseasepanel. Source: Eligibility statement prior genetic testing
WT1 was added to Proteinuric renal diseasepanel. Sources: Eligibility statement prior genetic testing