Proteinuric renal disease

Gene: WT1

Green List (high evidence)

WT1 (Wilms tumor 1)
EnsemblGeneIds (GRCh38): ENSG00000184937
EnsemblGeneIds (GRCh37): ENSG00000184937
OMIM: 607102, Gene2Phenotype
WT1 is in 21 panels

4 reviews

Eleanor Williams (Genomics England Curator)

Green List (high evidence)

This gene was part of an initial gene list collated by Elizabeth Watson, North Bristol NHS Trust, February 2019 on behalf of the GMS Renal Specialist Test Group. Gene Symbol submitted: WT1; Suggested initial gene rating: green; Evidence for inclusion: none provided; Other comments: Well reported association with nephrotic syndrome
Created: 4 Feb 2019, 10:41 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Denys-Drash syndrome #194080; Frasier syndrome #136680; Wilms tumor, type 1 #194070

Variants in this GENE are reported as part of current diagnostic practice

Ellen Thomas (Genomics England Curator)

Daniel Gale (UCL)

Green List (high evidence)

Maggie Williams (North Bristol NHS Trust)

Green List (high evidence)

Pathogenic variants exons 6-9. Multiple hits UK diagnostic panel
Created: 19 Oct 2015, 3:29 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Congenital onset, urogenital anomalies, sex reversal

Publications

  • Kidney International (2014) 85, 1169–1178

Variants in this GENE are reported as part of current diagnostic practice

History Filter Activity

19 Jun 2019, Gel status: 4

Set Phenotypes

Eleanor Williams (Genomics England Curator)

Phenotypes for gene: WT1 were changed from to Denys-Drash syndrome #194080; Frasier syndrome #136680; Wilms tumor, type 1 #194070

19 Jun 2019, Gel status: 4

Set publications

Eleanor Williams (Genomics England Curator)

Publications for gene: WT1 were set to

4 Feb 2019, Gel status: 3

Added New Source, Status Update

Eleanor Williams (Genomics England Curator)

Source NHS GMS was added to WT1. Rating Changed from Green List (high evidence) to Green List (high evidence)

27 May 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen Thomas (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

27 May 2016, Gel status: 4

Set Mode of Inheritance

Ellen Thomas (Genomics England Curator)

Mode of inheritance for WT1 was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

27 May 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen Thomas (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

28 Aug 2015, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

WT1 was added to Proteinuric renal diseasepanel. Source: Eligibility statement prior genetic testing

18 Aug 2015, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

WT1 was added to Proteinuric renal diseasepanel. Sources: Eligibility statement prior genetic testing