Cystic kidney disease
Gene: REN
REN (renin)
EnsemblGeneIds (GRCh38): ENSG00000143839
EnsemblGeneIds (GRCh37): ENSG00000143839
OMIM: 179820, Gene2Phenotype
REN is in 8 panels
EnsemblGeneIds (GRCh38): ENSG00000143839
EnsemblGeneIds (GRCh37): ENSG00000143839
OMIM: 179820, Gene2Phenotype
REN is in 8 panels
1 review
Aakash Joshi (St George's Hospital)
PMCID 11997664 identified in a cohort of 702 individuals with suspected inherited renal cystic disease that 1 individual had a monoallelic pathogenic REN variant. Would suggest this provides some evidence for inclusion but would be low (Red list).
Sources: LiteratureCreated: 1 Oct 2026, 12:10 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
cystic renal disease
Publications
- PMCID 11997664
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
- Sources
-
- Phenotypes
-
- cystic renal disease
- OMIM
- 179820
- Clinvar variants
- Variants in REN
- Penetrance
- unknown
- Publications
-
- PMCID 11997664
- Panels with this gene
History Filter Activity
1 Oct 2026, Gel status: 0
Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes, Set penetrance
Aakash Joshi (St George's Hospital)gene: REN was added gene: REN was added to Cystic kidney disease. Sources: Literature Mode of inheritance for gene: REN was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: REN were set to PMCID 11997664 Phenotypes for gene: REN were set to cystic renal disease Penetrance for gene: REN were set to unknown Review for gene: REN was set to RED