Skeletal dysplasia
Gene: TRPV6
Comment when marking as ready: Sufficient cases, relevant phenotype. Therefore considered green. Also I will add it to the thoracic dystrophies and OI panels in view of the presentation with small chest / respiratory distress and fractures.Created: 15 Jan 2019, 3:18 p.m.
Comment on list classification: Sufficient cases, relevant phenotypeCreated: 15 Jan 2019, 3:16 p.m.
6 unrelated children with skeletal abnormalities detected in the third trimester of pregnancy, who presented at birth with elevated serum PTH and alkaline phosphatase activity, with normal or low ionized calcium. Skeletal anomalies included generalized osteopenia, narrow chest, short ribs with multiple healing fractures, and bowing or fractures of long bones. All affected individuals experienced postnatal respiratory difficulties requiring ventilatory support in the first few weeks to months of life. In addition, most showed poor feeding, with some requiring tube feeding.
Sources: LiteratureCreated: 15 Jan 2019, 3:10 p.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Hyperparathyroidism, transient neonatal, 618188
Publications
Gene: trpv6 has been classified as Green List (High Evidence).
Gene: trpv6 has been classified as Green List (High Evidence).
gene: TRPV6 was added gene: TRPV6 was added to Skeletal dysplasia. Sources: Literature Mode of inheritance for gene: TRPV6 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: TRPV6 were set to 29861107 Phenotypes for gene: TRPV6 were set to Hyperparathyroidism, transient neonatal, 618188 Penetrance for gene: TRPV6 were set to unknown Review for gene: TRPV6 was set to GREEN