Familial prostate cancer
Gene: CHEK2
CHEK2 (checkpoint kinase 2)
EnsemblGeneIds (GRCh38): ENSG00000183765
EnsemblGeneIds (GRCh37): ENSG00000183765
OMIM: 604373, Gene2Phenotype
CHEK2 is in 9 panels
EnsemblGeneIds (GRCh38): ENSG00000183765
EnsemblGeneIds (GRCh37): ENSG00000183765
OMIM: 604373, Gene2Phenotype
CHEK2 is in 9 panels
1 review
Ellen McDonagh (Genomics England Curator)
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
{Prostate cancer, familial, susceptibility to}
Publications
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
- Sources
-
- Literature
- Phenotypes
-
- {Prostate cancer, familial, susceptibility to}
- OMIM
- 604373
- Clinvar variants
- Variants in CHEK2
- Penetrance
- Complete
- Publications
- Panels with this gene
-
- Adult solid tumours for rare disease
- Familial breast cancer
- Inherited predisposition to acute myeloid leukaemia (AML)
- Inherited breast cancer and ovarian cancer
- Inherited prostate cancer
- GI tract tumours
- Familial prostate cancer
- Adult solid tumours cancer susceptibility
- Inherited ovarian cancer (without breast cancer)
History Filter Activity
7 Mar 2017, Gel status: 0
panel promoted to version 1
Ellen McDonagh (Genomics England Curator)07/03/2017 - revised and ready to promote to version 1.
26 Jan 2017, Gel status: 0
Set Mode of Inheritance
Ellen McDonagh (Genomics England Curator)Mode of inheritance for CHEK2 was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
26 Jan 2017, Gel status: 0
Set Phenotypes
Ellen McDonagh (Genomics England Curator)Phenotypes for CHEK2 were set to {Prostate cancer, familial, susceptibility to}
26 Jan 2017, Gel status: 0
Created
Ellen McDonagh (Genomics England Curator)CHEK2 was created by ellenmcdonagh
26 Jan 2017, Gel status: 0
Added New Source
Ellen McDonagh (Genomics England Curator)CHEK2 was added to Familial prostate cancerpanel. Sources: Literature