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  3. MEN1
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Multiple endocrine tumours

Gene: MEN1

Green List (high evidence)
MEN1 (menin 1)
EnsemblGeneIds (GRCh38): ENSG00000133895
EnsemblGeneIds (GRCh37): ENSG00000133895
OMIM: 613733, Gene2Phenotype
MEN1 is in 16 panels

4 reviews

Louise IZATT (GSTT Clinical Genetics Service)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Created: 5 Nov 2017, 2:40 a.m.

Panel version: 0

Katie Snape (South London GMC)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Variants in this GENE are reported as part of current diagnostic practice

Created: 5 Nov 2017, 2:40 a.m.

Panel version: 0

Treena Cranston (Oxford)

Green List (high evidence)

Created: 5 Nov 2017, 2:40 a.m.

Panel version: 0

Sian Ellard (University of Exeter Medical School)

Green List (high evidence)

Created: 5 Nov 2017, 2:40 a.m.

Panel version: 0

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Eligibility statement prior genetic testing
  • Expert
  • Radboud University Medical Center, Nijmegen
  • Illumina TruGenome Clinical Sequencing Services
  • UKGTN
  • Emory Genetics Laboratory
Phenotypes
  • Multiple Endocrine Neoplasia Type 1: MEN1 Gene Deletion/Duplication
  • Multiple Endocrine Neoplasia
  • Multiple endocrine neoplasia 1, 131100
  • Carcinoid tumor of lung
  • Parathyroid adenoma, somatic
  • Lipoma, somatic
  • Angiofibroma, somatic
  • Adrenal adenoma, somatic
  • MEN1-like spectrum
  • pituitary tumours
  • Endocrine Cancer
OMIM
613733
Clinvar variants
Variants in MEN1
Penetrance
Complete
Panels with this gene

History Filter Activity

1 Feb 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

1 Feb 2016, Gel status: 4

Set Phenotypes

Ellen McDonagh (Genomics England Curator)

Phenotypes for MEN1 were set to Multiple Endocrine Neoplasia Type 1: MEN1 Gene Deletion/Duplication; Multiple Endocrine Neoplasia; Multiple endocrine neoplasia 1, 131100; Carcinoid tumor of lung; Parathyroid adenoma, somatic; Lipoma, somatic; Angiofibroma, somatic; Adrenal adenoma, somatic; MEN1-like spectrum; pituitary tumours; Endocrine Cancer

1 Feb 2016, Gel status: 4

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Mode of inheritance for MEN1 was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

20 Aug 2015, Gel status: 4

Set Phenotypes

Eik Haraldsdottir (Genomics England)

Phenotypes for gene MEN1 were set to Multiple Endocrine Neoplasia Type 1: MEN1 Gene Deletion/Duplication;Multiple Endocrine Neoplasia;Multiple endocrine neoplasia 1, 131100Carcinoid tumor of lung Parathyroid adenoma, somatic Lipoma, somatic Angiofibroma, somatic Adrenal adenoma, somatic;MEN1-like spectrum; pituitary tumours; Endocrine Cancer

12 Aug 2015, Gel status: 4

Added New Source

Ellen McDonagh (Genomics England Curator)

MEN1 was added to Multiple endocrine tumourspanel. Sources: Eligibility statement prior genetic testing

8 May 2015, Gel status: 4

Added New Source

Eik Haraldsdottir (Genomics England)

MEN1 was added to Multiple endocrine tumourspanel. Sources: Expert

28 Apr 2015, Gel status: 4

Added New Source

GEL ()

MEN1 was added to Multiple endocrine tumourspanel. Sources: Radboud University Medical Center, Nijmegen

28 Apr 2015, Gel status: 3

Added New Source

GEL ()

MEN1 was added to Multiple endocrine tumourspanel. Sources: Illumina TruGenome Clinical Sequencing Services

28 Apr 2015, Gel status: 2

Added New Source

GEL ()

MEN1 was added to Multiple endocrine tumourspanel. Sources: UKGTN

28 Apr 2015, Gel status: 1

Added New Source

GEL ()

MEN1 was added to Multiple endocrine tumourspanel. Sources: Emory Genetics Laboratory