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  2. Early onset or syndromic epilepsy
  3. GAL
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Early onset or syndromic epilepsy

Gene: GAL

Red List (low evidence)
GAL (galanin and GMAP prepropeptide)
EnsemblGeneIds (GRCh38): ENSG00000069482
EnsemblGeneIds (GRCh37): ENSG00000069482
OMIM: 137035, Gene2Phenotype
GAL is in 2 panels

3 reviews

Rebecca Foulger (Genomics England curator)

I don't know

Review and rating collated by Tracy Lester (Oxford Medical Genetics Laboratories Oxford University Hospitals NHS Foundation Trust, 2019_02_06) on behalf of Wessex and West Midlands GLH for GMS Neurology specialist test group, for Clinical Indication R59 'Early onset or syndromic epilepsy'. Review contributors: John Taylor and Helen Lord. Suggested gene rating: Amber.
Created: 6 Aug 2019, 8:38 p.m. | Last Modified: 6 Aug 2019, 8:38 p.m.
Panel Version: 1.189
Created: 6 Aug 2019, 8:38 p.m.
Last Modified: 6 Aug 2019, 8:38 p.m.
Panel version: 1.189

Tracy Lester (Genetics laboratory, Oxford UK)

I don't know

? AD familial temporal lobe epilepsy. Reported in a pair of monozygotic twin brothers, however no variants found in this gene when screening an additional 582 epilepsy patients.
Created: 6 Aug 2019, 8:31 p.m. | Last Modified: 6 Aug 2019, 8:31 p.m.
Panel Version: 1.188

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
?Epilepsy, familial temporal lobe, 8, 616461

Publications

Created: 6 Aug 2019, 8:31 p.m.
Last Modified: 6 Aug 2019, 8:31 p.m.
Panel version: 1.188

Sarah Leigh (Genomics England Curator)

Red List (low evidence)

Comment on list classification: Associated with phenotype in OMIM and not in Gen2Phen. At least one variant identified in monozygotic twins.
Created: 23 Jul 2018, 2:33 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
?Epilepsy, familial temporal lobe, 8 616461

Publications

Created: 23 Jul 2018, 2:30 p.m.

Panel version: 0.288

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Wessex and West Midlands GLH
  • NHS GMS
  • Expert Review Red
  • Literature
Phenotypes
  • ?Epilepsy, familial temporal lobe, 8 616461
OMIM
137035
Clinvar variants
Variants in GAL
Penetrance
None
Publications
Panels with this gene

History Filter Activity

6 Aug 2019, Gel status: 1

Added New Source

Rebecca Foulger (Genomics England curator)

Source Wessex and West Midlands GLH was added to GAL.

6 Aug 2019, Gel status: 1

Added New Source

Rebecca Foulger (Genomics England curator)

Source NHS GMS was added to GAL.

11 Dec 2018, Gel status: 1

Panel promoted to version 1.0

Sarah Leigh (Genomics England Curator)

Sarah Leigh: Comment on list classification

26 Sep 2018, Gel status: 1

Entity classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

Gene: gal has been classified as Red List (Low Evidence).

23 Jul 2018, Gel status: 1

Entity classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

Gene: gal has been classified as Red List (Low Evidence).

23 Jul 2018, Gel status: 1

Added New Source

Sarah Leigh (Genomics England Curator)

GAL was added to Genetic Epilepsy Syndromes panel. Sources: Literature

23 Jul 2018, Gel status: 1

Created

Sarah Leigh (Genomics England Curator)

GAL was created by Sarah Leigh