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Genetic epilepsy syndromes

Gene: GAL

Red List (low evidence)

GAL (galanin and GMAP prepropeptide)
EnsemblGeneIds (GRCh38): ENSG00000069482
EnsemblGeneIds (GRCh37): ENSG00000069482
OMIM: 137035, Gene2Phenotype
GAL is in 2 panels

3 reviews

Rebecca Foulger (Genomics England curator)

I don't know

Review and rating collated by Tracy Lester (Oxford Medical Genetics Laboratories Oxford University Hospitals NHS Foundation Trust, 2019_02_06) on behalf of Wessex and West Midlands GLH for GMS Neurology specialist test group, for Clinical Indication R59 'Early onset or syndromic epilepsy'. Review contributors: John Taylor and Helen Lord. Suggested gene rating: Amber.
Created: 6 Aug 2019, 8:38 p.m. | Last Modified: 6 Aug 2019, 8:38 p.m.
Panel Version: 1.189

Tracy Lester (Genetics laboratory, Oxford UK)

I don't know

? AD familial temporal lobe epilepsy. Reported in a pair of monozygotic twin brothers, however no variants found in this gene when screening an additional 582 epilepsy patients.
Created: 6 Aug 2019, 8:31 p.m. | Last Modified: 6 Aug 2019, 8:31 p.m.
Panel Version: 1.188

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
?Epilepsy, familial temporal lobe, 8, 616461

Publications

Sarah Leigh (Genomics England Curator)

Red List (low evidence)

Comment on list classification: Associated with phenotype in OMIM and not in Gen2Phen. At least one variant identified in monozygotic twins.
Created: 23 Jul 2018, 2:33 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
?Epilepsy, familial temporal lobe, 8 616461

Publications

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Wessex and West Midlands GLH
  • NHS GMS
  • Expert Review Red
  • Literature
Phenotypes
  • ?Epilepsy, familial temporal lobe, 8 616461
OMIM
137035
Clinvar variants
Variants in GAL
Penetrance
None
Publications
Panels with this gene

History Filter Activity

6 Aug 2019, Gel status: 1

Added New Source

Rebecca Foulger (Genomics England curator)

Source Wessex and West Midlands GLH was added to GAL.

6 Aug 2019, Gel status: 1

Added New Source

Rebecca Foulger (Genomics England curator)

Source NHS GMS was added to GAL.

11 Dec 2018, Gel status: 1

Panel promoted to version 1.0

Sarah Leigh (Genomics England Curator)

Sarah Leigh: Comment on list classification

26 Sep 2018, Gel status: 1

Entity classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

Gene: gal has been classified as Red List (Low Evidence).

23 Jul 2018, Gel status: 1

Entity classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

Gene: gal has been classified as Red List (Low Evidence).

23 Jul 2018, Gel status: 1

Added New Source

Sarah Leigh (Genomics England Curator)

GAL was added to Genetic Epilepsy Syndromes panel. Sources: Literature

23 Jul 2018, Gel status: 1

Created

Sarah Leigh (Genomics England Curator)

GAL was created by Sarah Leigh