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  2. Ataxia and cerebellar anomalies - narrow panel
  3. TGM6
Genes in panel
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Ataxia and cerebellar anomalies - narrow panel

Gene: TGM6

Amber List (moderate evidence)
TGM6 (transglutaminase 6)
EnsemblGeneIds (GRCh38): ENSG00000166948
EnsemblGeneIds (GRCh37): ENSG00000166948
OMIM: 613900, Gene2Phenotype
TGM6 is in 6 panels

3 reviews

Eleanor Williams (Genomics England Curator)

I don't know

The rating of this gene has been updated to amber following NHS Genomic Medicine Service approval.
Created: 5 Feb 2023, 5:18 p.m. | Last Modified: 5 Feb 2023, 5:18 p.m.
Panel Version: 3.30
Created: 5 Feb 2023, 5:18 p.m.
Last Modified: 5 Feb 2023, 5:18 p.m.
Panel version: 3.30

Ivone Leong (Genomics England Curator)

This gene has been tagged for review by the GMS specialist group with a recommendation to demote from Green to Red gene status.
Created: 4 May 2021, 1:58 p.m. | Last Modified: 4 May 2021, 1:58 p.m.
Panel Version: 2.153
Created: 4 May 2021, 1:58 p.m.
Last Modified: 4 May 2021, 1:58 p.m.
Panel version: 2.153

Zornitza Stark (Australian Genomics)

Red List (low evidence)

Causation disputed. Gene is rated Red on the Hereditary Ataxia, adult onset panel.
Created: 13 Sep 2020, 7:16 a.m. | Last Modified: 13 Sep 2020, 7:16 a.m.
Panel Version: 2.12

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Spinocerebellar ataxia 35, MIM# 613908

Publications

Created: 13 Sep 2020, 7:16 a.m.
Last Modified: 13 Sep 2020, 7:16 a.m.
Panel version: 2.12

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Amber
  • NHS GMS
Phenotypes
  • Spinocerebellar ataxia 35, OMIM:613908
OMIM
613900
Clinvar variants
Variants in TGM6
Penetrance
None
Publications
Panels with this gene

History Filter Activity

5 Feb 2023, Gel status: 2

Removed Tag, Removed Tag

Eleanor Williams (Genomics England Curator)

Tag Q2_21_rating was removed from gene: TGM6. Tag Q2_21_expert_review was removed from gene: TGM6.

5 Feb 2023, Gel status: 2

Added New Source, Added New Source, Status Update

Eleanor Williams (Genomics England Curator)

Source NHS GMS was added to TGM6. Source Expert Review Amber was added to TGM6. Rating Changed from Green List (high evidence) to Amber List (moderate evidence)

4 May 2021, Gel status: 3

Added Tag

Ivone Leong (Genomics England Curator)

Tag Q2_21_rating tag was added to gene: TGM6.

4 May 2021, Gel status: 3

Added Tag

Ivone Leong (Genomics England Curator)

Tag Q2_21_expert_review tag was added to gene: TGM6.

4 May 2021, Gel status: 3

Set Phenotypes

Ivone Leong (Genomics England Curator)

Phenotypes for gene: TGM6 were changed from Spinocerebellar ataxia 35, 613908 to Spinocerebellar ataxia 35, OMIM:613908

4 May 2021, Gel status: 3

Set publications

Ivone Leong (Genomics England Curator)

Publications for gene: TGM6 were set to 32426513; 30670339

4 May 2021, Gel status: 3

Set publications

Ivone Leong (Genomics England Curator)

Publications for gene: TGM6 were set to

9 Jan 2019, Gel status: 4

Panel promoted to version 1.0

Louise Daugherty (Genomics England Curator)

Checked against super panel made up of the panel constituents. Ready to promote to version 1.

9 Jan 2019, Gel status: 4

Set Phenotypes

Louise Daugherty (Genomics England Curator)

Phenotypes for gene: TGM6 were changed from Spinocerebellar ataxia 35 to Spinocerebellar ataxia 35, 613908

19 Dec 2018, Gel status: 4

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: TGM6 was added gene: TGM6 was added to Ataxia and cerebellar anomalies - narrow panel. Sources: Expert Review Green Mode of inheritance for gene: TGM6 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Phenotypes for gene: TGM6 were set to Spinocerebellar ataxia 35