Ataxia and cerebellar anomalies - narrow panel
Gene: TGM6
The rating of this gene has been updated to amber following NHS Genomic Medicine Service approval.Created: 5 Feb 2023, 5:18 p.m. | Last Modified: 5 Feb 2023, 5:18 p.m.
Panel Version: 3.30
This gene has been tagged for review by the GMS specialist group with a recommendation to demote from Green to Red gene status.Created: 4 May 2021, 1:58 p.m. | Last Modified: 4 May 2021, 1:58 p.m.
Panel Version: 2.153
Causation disputed. Gene is rated Red on the Hereditary Ataxia, adult onset panel.Created: 13 Sep 2020, 7:16 a.m. | Last Modified: 13 Sep 2020, 7:16 a.m.
Panel Version: 2.12
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Spinocerebellar ataxia 35, MIM# 613908
Publications
Tag Q2_21_rating was removed from gene: TGM6. Tag Q2_21_expert_review was removed from gene: TGM6.
Source NHS GMS was added to TGM6. Source Expert Review Amber was added to TGM6. Rating Changed from Green List (high evidence) to Amber List (moderate evidence)
Tag Q2_21_rating tag was added to gene: TGM6.
Tag Q2_21_expert_review tag was added to gene: TGM6.
Phenotypes for gene: TGM6 were changed from Spinocerebellar ataxia 35, 613908 to Spinocerebellar ataxia 35, OMIM:613908
Publications for gene: TGM6 were set to 32426513; 30670339
Publications for gene: TGM6 were set to
Checked against super panel made up of the panel constituents. Ready to promote to version 1.
Phenotypes for gene: TGM6 were changed from Spinocerebellar ataxia 35 to Spinocerebellar ataxia 35, 613908
gene: TGM6 was added gene: TGM6 was added to Ataxia and cerebellar anomalies - narrow panel. Sources: Expert Review Green Mode of inheritance for gene: TGM6 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Phenotypes for gene: TGM6 were set to Spinocerebellar ataxia 35