Paediatric disorders - additional genes
Gene: GATA3The rating of this gene has been updated following NHS Genomic Medicine Service approval.Created: 10 Mar 2022, 3:53 p.m. | Last Modified: 10 Mar 2022, 3:53 p.m.
Panel Version: 1.96
Comment on list classification: Changed rating to Amber so that Green genes on this panel reflect the NHS signed-off version. This will be reviewed at the next GMS panel update.Created: 19 Oct 2020, 2:15 p.m. | Last Modified: 19 Oct 2020, 2:15 p.m.
Panel Version: 1.58
Comment on list classification: Updated from Amber to Green awaiting GLH review. GATA3 HDR syndrome includes hypoparathyroidism and sensorineural deafness in addition to renal dysplasia.Created: 14 May 2020, 3:50 p.m. | Last Modified: 14 May 2020, 3:50 p.m.
Panel Version: 1.43
PMID:11389161. Muroya et al., 2001 report 9 Japanese families with HDR syndrome (hypoparathyroidism, sensorineural deafness, and renal dysplasia). Heterozygous gross deletions were reported by FISH in 4 families. Sequence analysis showed heterozygous novel variants in 3 families. 2 families had no GATA3 abnormalities detected.Created: 14 May 2020, 3:49 p.m. | Last Modified: 14 May 2020, 3:49 p.m.
Panel Version: 1.42
GATA3 has an Amber rating on Clefting panel v2.3.Created: 14 May 2020, 3:42 p.m. | Last Modified: 14 May 2020, 3:42 p.m.
Panel Version: 1.42
Added 'for-review' tag: Requires GLH review as to whether CAKUT phenotype is sufficient for inclusion on Paediatric disorders panel.Created: 12 May 2020, 4:16 p.m. | Last Modified: 12 May 2020, 4:16 p.m.
Panel Version: 1.4
Added to Paediatric disorders - additional genes panel, based on Green rating on CAKUT panel V1.106. Note that GATA3 is on V14.137 Paediatric panel already but with Amber rating.Created: 12 May 2020, 3:57 p.m. | Last Modified: 12 May 2020, 3:57 p.m.
Panel Version: 1.4
Tag for-review was removed from gene: GATA3.
Source Expert Review Green was added to GATA3. Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Gene: gata3 has been classified as Amber List (Moderate Evidence).
Gene: gata3 has been classified as Green List (High Evidence).
Gene: gata3 has been classified as Amber List (Moderate Evidence).
Gene: gata3 has been classified as Amber List (Moderate Evidence).
Tag for-review tag was added to gene: GATA3.
gene: GATA3 was added gene: GATA3 was added to Paediatric disorders - additional genes. Sources: Other,Expert Review Green Mode of inheritance for gene: GATA3 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: GATA3 were set to CAKUT; Hypoparathyroidism, sensorineural deafness, and renal dysplasia, 146255; Hypoparathyroidism, Sensorineural Deafness, and Renal Disease