Paediatric disorders - additional genes
Gene: AGTThe rating of this gene has been updated following NHS Genomic Medicine Service approval.Created: 10 Mar 2022, 3:53 p.m. | Last Modified: 10 Mar 2022, 3:53 p.m.
Panel Version: 1.96
Comment on list classification: Kept rating as Amber for now: renal tubulogenesis is key phenotype and therefore CAKUT may be isolated.Created: 14 May 2020, 1:30 p.m. | Last Modified: 14 May 2020, 1:30 p.m.
Panel Version: 1.27
PMID:16116425. Gribouval et al. 2005 studied 9 families (11 indivs) with AR renal tubular dysgenesis, and found variants in REN, AGT, ACE or AGTR1.Created: 12 May 2020, 8:07 p.m. | Last Modified: 12 May 2020, 8:07 p.m.
Panel Version: 1.21
Added 'for-review' tag: Requires GLH review as to whether CAKUT phenotype is sufficient for inclusion on Paediatric disorders panel.Created: 12 May 2020, 4:15 p.m. | Last Modified: 12 May 2020, 4:15 p.m.
Panel Version: 1.4
Added to Paediatric disorders - additional genes panel, based on Green rating on CAKUT panel V1.106. Note that AGT is on V14.137 Paediatric disorders panel already but with Red rating.Created: 12 May 2020, 3:57 p.m. | Last Modified: 12 May 2020, 8:07 p.m.
Panel Version: 1.21
Tag for-review was removed from gene: AGT.
Source Expert Review Green was added to AGT. Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Gene: agt has been classified as Amber List (Moderate Evidence).
Phenotypes for gene: AGT were changed from CAKUT; {Hypertension, essential, susceptibility to}, 145500{Preeclampsia, susceptibility to}Renal tubular dysgenesis, 267430; Renal Tubular Dysgenesis to Renal tubular dysgenesis, 267430; CAKUT
Publications for gene: AGT were set to
Gene: agt has been classified as Amber List (Moderate Evidence).
Tag for-review tag was added to gene: AGT.
gene: AGT was added gene: AGT was added to Paediatric disorders - additional genes. Sources: Other,Expert Review Green Mode of inheritance for gene: AGT was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: AGT were set to CAKUT; {Hypertension, essential, susceptibility to}, 145500{Preeclampsia, susceptibility to}Renal tubular dysgenesis, 267430; Renal Tubular Dysgenesis