Inherited predisposition to GIST
Gene: SDHCComment on phenotypes: This gene is also associated with Paragangliomas 3 (MIM# 605373)Created: 8 Mar 2021, 12:21 p.m. | Last Modified: 8 Mar 2021, 12:21 p.m.
Panel Version: 1.9
As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that there is enough evidence to rate this gene green.Created: 31 Jul 2019, 1:06 p.m. | Last Modified: 31 Jul 2019, 1:06 p.m.
Panel Version: 0.21
Variants in this GENE are reported as part of current diagnostic practice
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Familial Paraganglioma and Pheochromocytoma
Phenotypes for gene: SDHC were changed from to Gastrointestinal stromal tumor, OMIM:606764; Paraganglioma and gastric stromal sarcoma, OMIM:606864; Carney-Stratakis syndrome, MONDO:0011740
Mode of inheritance for gene: SDHC was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Gene: sdhc has been classified as Green List (High Evidence).
gene: SDHC was added gene: SDHC was added to Inherited predisposition to GIST. Sources: Expert List,NHS GMS Mode of inheritance for gene: SDHC was set to