SDHC

succinate dehydrogenase complex subunit C
OMIM: 602413, Gene2Phenotype

16 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 16 panels
Green SDHC in Neuroendocrine cancer pertinent cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 1.4	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Expert list Phenotypes Neuroendocrine cancer
Green SDHC in Adult solid tumours for rare disease Level 3: Tumour syndromes Level 2: Tumour syndromes Version 1.40	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert list Expert Review Green Phenotypes Familial Paraganglioma and Pheochromocytoma
Amber SDHC in Inherited renal cancer Version 1.27 Latest signed off version: v1.2 (4 Mar 2020)	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Amber UKGTN Phenotypes Renal cell carcinoma (disease), MONDO:0005086
Green SDHC in Inherited predisposition to GIST Version 1.14 Latest signed off version: v1.2 (4 Mar 2020)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green NHS GMS Expert List Phenotypes Gastrointestinal stromal tumor, OMIM:606764 Paraganglioma and gastric stromal sarcoma, OMIM:606864 Carney-Stratakis syndrome, MONDO:0011740
Green SDHC in Multiple endocrine tumours Level 3: Breast and endocrine Level 2: Tumour syndromes Version 1.14	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Emory Genetics Laboratory Phenotypes Endocrine Cancer
Green SDHC in Inherited phaeochromocytoma and paraganglioma Level 3: Breast and endocrine Level 2: Tumour syndromes Version 1.11	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Eligibility statement prior genetic testing Expert UKGTN Illumina TruGenome Clinical Sequencing Services Emory Genetics Laboratory Radboud University Medical Center, Nijmegen Phenotypes Paragangliomas 3, 605373Paraganglioma and gastric stromal sarcoma, 606864Gastrointestinal stromal tumor, 606764 Hereditary Paraganglioma-Pheochromocytoma Syndrome
Green SDHC in Inherited phaeochromocytoma and paraganglioma excluding NF1 Version 2.6 Latest signed off version: v2.0 (30 Nov 2022)	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green NHS GMS Phenotypes Hereditary Paraganglioma-Pheochromocytoma Syndrome Paragangliomas 3, 605373Paraganglioma and gastric stromal sarcoma, 606864Gastrointestinal stromal tumor, 606764
Amber SDHC in Sarcoma cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 1.25	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Amber Expert List
Green SDHC in Adult solid tumours cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 2.29 Latest signed off version: v2.2 (18 Feb 2020)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources NHS GMS Expert Review Green Expert list Phenotypes Familial Paraganglioma and Pheochromocytoma
Amber SDHC in Mitochondrial disorder with complex II deficiency Version 2.10 Latest signed off version: v2.2 (22 Mar 2023)	review	Unknown	Sources Expert Review Amber NHS GMS Phenotypes No OMIM phenotype
Amber SDHC in Undiagnosed metabolic disorders Level 3: Specific metabolic abnormalities Level 2: Metabolic disorders Version 1.617	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Amber Literature Phenotypes Complex II (Mitochondrial respiratory chain disorders (caused by nuclear variants only), OXPHOS structural subunits) Multiple endocrine tumours Multiple Tumours Neuro-endocrine Tumours- PCC and PGL
Amber SDHC in Likely inborn error of metabolism - targeted testing not possible Version 4.137 Latest signed off version: v4.0 (22 Mar 2023) Component of the following Super Panels: Childhood onset leukodystrophy Hypotonic infant Paediatric disorders Unexplained death in infancy and sudden unexplained death in childhood	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources London North GLH NHS GMS Expert Review Amber Phenotypes Mitochondrial Diseases Isolated complex II deficiency Neuro-endocrine Tumours- PCC and PGL Multiple endocrine tumours Complex II (Mitochondrial respiratory chain disorders (caused by nuclear variants only), OXPHOS structural subunits) Multiple Tumours
Amber SDHC in Possible mitochondrial disorder - nuclear genes Version 3.105 Latest signed off version: v3.0 (22 Mar 2023)	review	Unknown	Sources Expert Review Amber NHS GMS Phenotypes No OMIM phenotype
Red SDHC in Mitochondrial disorders Level 3: Mitochondrial Level 2: Metabolic disorders Version 4.168 Latest signed off version: v4.0 (22 Mar 2023) Component of the following Super Panels: Childhood onset leukodystrophy	review	Not set	Sources Expert list Expert Emory Genetics Laboratory Phenotypes Mitochondrial Diseases Isolated complex II deficiency
Amber SDHC in Sarcoma susceptibility Version 1.81 Latest signed off version: v1.2 (18 Feb 2020)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources NHS GMS Expert Review Amber Expert Review Amber Expert List Phenotypes Paraganglioma and gastric stromal sarcoma, OMIM:606864 Carney-Stratakis syndrome, MONDO:0011740
Red SDHC in Childhood onset dystonia, chorea or related movement disorder Version 3.75 Latest signed off version: v3.0 (22 Mar 2023)	review	Not set	Sources Expert Review Red London North GLH