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  2. Inherited phaeochromocytoma and paraganglioma
  3. SDHC
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Inherited phaeochromocytoma and paraganglioma

Gene: SDHC

Green List (high evidence)
SDHC (succinate dehydrogenase complex subunit C)
EnsemblGeneIds (GRCh38): ENSG00000143252
EnsemblGeneIds (GRCh37): ENSG00000143252
OMIM: 602413, Gene2Phenotype
SDHC is in 16 panels

3 reviews

Louise IZATT (GSTT Clinical Genetics Service)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Created: 5 Nov 2017, 2:37 a.m.

Panel version: 0

Katie Snape (South London GMC)

Green List (high evidence)

Created: 5 Nov 2017, 2:37 a.m.

Panel version: 0

Treena Cranston (Oxford)

Green List (high evidence)

UKGTN approved
Created: 30 Sep 2015, 11:42 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
PGL; PCC

Publications

Variants in this GENE are reported as part of current diagnostic practice

Created: 30 Sep 2015, 11:42 a.m.

Panel version: 0

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Eligibility statement prior genetic testing
  • Expert
  • UKGTN
  • Illumina TruGenome Clinical Sequencing Services
  • Emory Genetics Laboratory
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • Paragangliomas 3, 605373Paraganglioma and gastric stromal sarcoma, 606864Gastrointestinal stromal tumor, 606764
  • Hereditary Paraganglioma-Pheochromocytoma Syndrome
OMIM
602413
Clinvar variants
Variants in SDHC
Penetrance
Complete
Panels with this gene

History Filter Activity

6 Feb 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen Thomas (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

6 Feb 2016, Gel status: 4

Set Mode of Inheritance

Ellen Thomas (Genomics England Curator)

Mode of inheritance for SDHC was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

12 Aug 2015, Gel status: 4

Added New Source

Ellen McDonagh (Genomics England Curator)

SDHC was added to Neuro-endocrine Tumours- PCC and PGLpanel. Sources: Eligibility statement prior genetic testing

8 May 2015, Gel status: 4

Added New Source

Eik Haraldsdottir (Genomics England)

SDHC was added to Neuro-endocrine Tumours- PCC and PGLpanel. Sources: Expert

28 Apr 2015, Gel status: 4

Added New Source

GEL ()

SDHC was added to Neuro-endocrine Tumours- PCC and PGLpanel. Sources: UKGTN

28 Apr 2015, Gel status: 3

Added New Source

GEL ()

SDHC was added to Neuro-endocrine Tumours- PCC and PGLpanel. Sources: Illumina TruGenome Clinical Sequencing Services

28 Apr 2015, Gel status: 2

Added New Source

GEL ()

SDHC was added to Neuro-endocrine Tumours- PCC and PGLpanel. Sources: Emory Genetics Laboratory

28 Apr 2015, Gel status: 1

Added New Source

GEL ()

SDHC was added to Neuro-endocrine Tumours- PCC and PGLpanel. Sources: Radboud University Medical Center, Nijmegen