Inherited phaeochromocytoma and paraganglioma
Gene: NF1EnsemblGeneIds (GRCh38): ENSG00000196712
EnsemblGeneIds (GRCh37): ENSG00000196712
OMIM: 613113, Gene2Phenotype
NF1 is in 32 panels
4 reviews
Louise IZATT (GSTT Clinical Genetics Service)
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Katie Snape (South London GMC)
Ellen Thomas (Genomics England Curator)
Comment on list classification: Well characterised disease gene with phenotypic overlap with this disorder.Created: 7 Feb 2016, 8:53 p.m.
Treena Cranston (Oxford)
PCC is rare, but can be seen in association with NF1, not generally seen as isolated PCC so currently not included in standard isolated PCC/PGL testingCreated: 30 Sep 2015, 12:21 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
NF1
Publications
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
- Sources
-
- Expert Review Green
- UKGTN
- Phenotypes
-
- NF1
- OMIM
- 613113
- Clinvar variants
- Variants in NF1
- Penetrance
- Complete
- Publications
- Panels with this gene
-
- Pigmentary skin disorders
- Inherited predisposition to GIST
- Familial pulmonary fibrosis
- Segmental or atypical neurofibromatosis type 1 testing
- Mosaic skin disorders - deep sequencing
- Cerebral vascular malformations
- Familial rhabdomyosarcoma
- Haematological malignancies for rare disease
- DDG2P
- RASopathies
- Inherited phaeochromocytoma and paraganglioma excluding NF1
- Haematological malignancies cancer susceptibility
- Skeletal dysplasia
- Childhood solid tumours cancer susceptibility
- Fetal anomalies
- Inherited phaeochromocytoma and paraganglioma
- Paediatric or syndromic cardiomyopathy
- Multiple monogenic benign skin tumours
- Familial Tumours Syndromes of the central & peripheral Nervous system
- Sarcoma cancer susceptibility
- Primary lymphoedema
- Cytopenias and congenital anaemias
- Neurofibromatosis Type 1
- Monogenic short stature
- Intellectual disability
- Hydrocephalus
- Childhood solid tumours
- Monogenic hearing loss
- Adult solid tumours for rare disease
- Sarcoma susceptibility
- Adult solid tumours cancer susceptibility
- Neurofibromatosis type 1 (GMS)
History Filter Activity
Gene classified by Genomics England curator
Ellen Thomas (Genomics England Curator)This gene has been classified as Green List (High Evidence).
Set publications
Ellen Thomas (Genomics England Curator)Publications for NF1 were set to 22429592; 16735498; UKGTN
Set Phenotypes
Ellen Thomas (Genomics England Curator)Phenotypes for NF1 were set to NF1
Set Mode of Inheritance
Ellen Thomas (Genomics England Curator)Mode of inheritance for NF1 was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Gene classified by Genomics England curator
Ellen Thomas (Genomics England Curator)This gene has been classified as Green List (High Evidence).
Added New Source
GEL ()NF1 was added to Neuro-endocrine Tumours- PCC and PGLpanel. Sources: UKGTN