Inherited phaeochromocytoma and paraganglioma

Gene: TP53

Red List (low evidence)

TP53 (tumor protein p53)
EnsemblGeneIds (GRCh38): ENSG00000141510
EnsemblGeneIds (GRCh37): ENSG00000141510
OMIM: 191170, Gene2Phenotype
TP53 is in 23 panels

2 reviews

Louise IZATT (GSTT Clinical Genetics Service)

Red List (low evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Treena Cranston (Oxford)

Red List (low evidence)

low evidence of germline mutations being causative of PCC/PGL
Created: 13 Oct 2015, 8:48 a.m.

History Filter Activity

20 Apr 2016, Gel status: 1

Gene classified by Genomics England curator

Ellen Thomas (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

17 Aug 2015, Gel status: 1

Set Phenotypes

Eik Haraldsdottir (Genomics England)

Phenotypes for gene TP53 were set to test

28 Apr 2015, Gel status: 1

Added New Source

GEL ()

TP53 was added to Neuro-endocrine Tumours- PCC and PGLpanel. Sources: Emory Genetics Laboratory