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Inherited pancreatic cancer

Gene: STK11

Green List (high evidence)
STK11 (serine/threonine kinase 11)
EnsemblGeneIds (GRCh38): ENSG00000118046
EnsemblGeneIds (GRCh37): ENSG00000118046
OMIM: 602216, Gene2Phenotype
STK11 is in 14 panels

7 reviews

Achchuthan Shanmugasundram (Genomics England Curator)

Green List (high evidence)

The rating of this gene has been updated to green following NHS Genomic Medicine Service approval.
Created: 5 Dec 2024, 10:15 p.m. | Last Modified: 5 Dec 2024, 10:15 p.m.
Panel Version: 2.9

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Created: 5 Dec 2024, 10:15 p.m.
Last Modified: 5 Dec 2024, 10:15 p.m.
Panel version: 2.9

Sarah Leigh (Genomics England Curator)

Green List (high evidence)

STK11 should be rated as green, based on the consensus reached at UKCGG/Cancer Leads meeting 29th February 2024.
Created: 4 Jun 2024, 2:40 p.m. | Last Modified: 4 Jun 2024, 2:40 p.m.
Panel Version: 2.5
Created: 4 Jun 2024, 2:40 p.m.
Last Modified: 4 Jun 2024, 2:40 p.m.
Panel version: 2.5

Terri McVeigh (Royal Marsden NHS Foundation Trust)

Green List (high evidence)

Discussed at UKCGG/Cancer Leads meeting 29th February 2024 - consensus that STK11 should be added to this panel for diagnostic testing in individuals with pancreatic cancer fulfilling eligibility criteria.
Created: 22 May 2024, 8:25 a.m. | Last Modified: 22 May 2024, 8:25 a.m.
Panel Version: 2.3

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Peutz-Jeghers syndrome

Publications

Created: 22 May 2024, 8:25 a.m.
Last Modified: 22 May 2024, 8:25 a.m.
Panel version: 2.3

Ivone Leong (Genomics England Curator)

Comment on list classification: As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that this gene should be rated red.
Created: 1 Feb 2019, 10:13 a.m.
Created: 1 Feb 2019, 10:13 a.m.

Panel version: 0.28

Rachel Robinson (Leeds Genetics Laboratory)

Green List (high evidence)

Publications

Variants in this GENE are reported as part of current diagnostic practice

Created: 30 Jan 2019, 10:34 a.m.

Panel version: 0.3

Ellen McDonagh (Genomics England Curator)

Comment on mode of pathogenicity: Confirmed with Clare Turnbull that loss-of-function variants should be reported in this gene.
Created: 16 Mar 2018, 9:48 a.m.
Created: 16 Mar 2018, 9:48 a.m.

Panel version: Imported from Adult solid tumours pertinent cancer susceptibility panel version 0.22

Clare Turnbull (Queen Mary University London)

Green List (high evidence)

Tumor Suppressor. Gain of function.
Created: 5 Jul 2017, 12:19 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
Peutz Jeghers syndrome

Mode of pathogenicity
Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype -please provide details in the comments

Created: 5 Jul 2017, 12:19 p.m.

Panel version: Imported from Adult solid tumours pertinent cancer susceptibility panel version 0.2

History Filter Activity

5 Dec 2024, Gel status: 3

Removed Tag, Removed Tag

Achchuthan Shanmugasundram (Genomics England Curator)

Tag Q2_24_promote_green was removed from gene: STK11. Tag Q2_24_NHS_review was removed from gene: STK11.

5 Dec 2024, Gel status: 3

Added New Source, Status Update

Achchuthan Shanmugasundram (Genomics England Curator)

Source Expert Review Green was added to STK11. Rating Changed from Amber List (moderate evidence) to Green List (high evidence)

4 Jun 2024, Gel status: 2

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for gene: STK11 were changed from Pancreatic cancer, somatic, OMIM:260350 to Pancreatic cancer, somatic, OMIM:260350; familial pancreatic carcinoma, MONDO:0015278

4 Jun 2024, Gel status: 2

Set publications

Sarah Leigh (Genomics England Curator)

Publications for gene: STK11 were set to 30558719

4 Jun 2024, Gel status: 2

Added Tag, Added Tag

Sarah Leigh (Genomics England Curator)

Tag Q2_24_promote_green tag was added to gene: STK11. Tag Q2_24_NHS_review tag was added to gene: STK11.

4 Jun 2024, Gel status: 2

Entity classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

Gene: stk11 has been classified as Amber List (Moderate Evidence).

3 Mar 2021, Gel status: 1

Set Phenotypes

Arina Puzriakova (Genomics England Curator)

Phenotypes for gene: STK11 were changed from to Pancreatic cancer, somatic, OMIM:260350

15 Oct 2019, Gel status: 1

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: STK11 were set to

1 Feb 2019, Gel status: 1

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: stk11 has been classified as Red List (Low Evidence).

30 Jan 2019, Gel status: 3

Set mode of inheritance

Ivone Leong (Genomics England Curator)

Mode of inheritance for gene: STK11 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

30 Jan 2019, Gel status: 3

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: stk11 has been classified as Green List (High Evidence).

30 Jan 2019, Gel status: 1

Created, Added New Source, Set mode of inheritance

Ivone Leong (Genomics England Curator)

gene: STK11 was added gene: STK11 was added to Inherited pancreatic cancer. Sources: NHS GMS Mode of inheritance for gene: STK11 was set to