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  2. Laterality disorders and isomerism
  3. DAND5
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Laterality disorders and isomerism

Gene: DAND5

Red List (low evidence)
DAND5 (DAN domain BMP antagonist family member 5)
EnsemblGeneIds (GRCh38): ENSG00000179284
EnsemblGeneIds (GRCh37): ENSG00000179284
OMIM: 609068, Gene2Phenotype
DAND5 is in 2 panels

1 review

Arina Puzriakova (Genomics England Curator)

In a single individual with heterotaxy and congenital heart defects of L-R patterning, Bolkier et al., 2022 (PMID:34215651) identified a homozygous truncating (c.396_397dupCT) variant in the DAND5 gene.
Sources: Literature
Created: 13 Jul 2022, 4:06 p.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Heterotaxy syndrome

Publications

Created: 13 Jul 2022, 4:06 p.m.

Panel version: 1.51

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Literature
Phenotypes
  • Heterotaxy syndrome
OMIM
609068
Clinvar variants
Variants in DAND5
Penetrance
None
Publications
Panels with this gene

History Filter Activity

13 Jul 2022, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Arina Puzriakova (Genomics England Curator)

gene: DAND5 was added gene: DAND5 was added to Laterality disorders and isomerism. Sources: Literature Mode of inheritance for gene: DAND5 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: DAND5 were set to 34215651 Phenotypes for gene: DAND5 were set to Heterotaxy syndrome