Laterality disorders and isomerism
Gene: DAW1The OMIM entry for this gene is OMIM:620279, which has been cross-checked with Ensembl, HGNC and G2P. Hence, gene-checked tag has been added.Created: 17 Oct 2023, 9:42 a.m. | Last Modified: 17 Oct 2023, 9:42 a.m.
Panel Version: 3.4
Comment on list classification: There is enough evidence for this gene to be rated GREEN at the next major review, according to the recommendations from Helen Brittain (Genomics England, Clinical Fellow).Created: 25 Oct 2022, 2:05 p.m. | Last Modified: 25 Oct 2022, 2:25 p.m.
Panel Version: 1.53
DAW1 is not in OMIM, Gen2Phen or MONDO. PMID: 36074124 reports five variants in four unrelated cases with a motile ciliopathy / laterality disorder. Supportive functional studies and a mouse model were also reported in PMID: 36074124.
Sources: LiteratureCreated: 25 Oct 2022, 12:54 p.m. | Last Modified: 25 Oct 2022, 12:59 p.m.
Panel Version: 1.52
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
motile ciliopathy laterality disorder
Publications
Tag gene-checked tag was added to gene: DAW1.
Gene: daw1 has been classified as Amber List (Moderate Evidence).
gene: DAW1 was added gene: DAW1 was added to Laterality disorders and isomerism. Sources: Literature Q4_22_MOI, Q4_22_promote_green tags were added to gene: DAW1. Mode of inheritance for gene: DAW1 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: DAW1 were set to 36074124; 28991257 Phenotypes for gene: DAW1 were set to motile ciliopathy laterality disorder Review for gene: DAW1 was set to GREEN