Laterality disorders and isomerismGene: TTC25
Added new-gene-name tag, new approved HGNC gene symbol for TTC25 is ODAD4
Created: 24 Feb 2021, 5:11 p.m. | Last Modified: 24 Feb 2021, 5:11 p.m.
Panel Version: 1.21
Currently on CGGL Royal Brompton panel. Good but very limited published evidence.
Created: 25 Nov 2019, 11:25 p.m. | Last Modified: 25 Nov 2019, 11:25 p.m.
Panel Version: 0.51
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
OMIM 617092 Ciliary dyskinesia, primary, 35
Variants in this GENE are reported as part of current diagnostic practice
Comment on list classification: Downgraded from Green to Amber after expert review. Change of rating will be included in update with Test Group to enable further comment/review if required before sign off.
Created: 27 Nov 2019, 1:11 p.m. | Last Modified: 27 Nov 2019, 1:11 p.m.
Panel Version: 0.135
From GMS Respiratory Specialist Test Group webex call 18th Jan 2019 : there are unpublished cases and functional evidence to support this gene to be rated as Green.
Created: 21 Jan 2019, 4:51 p.m.
Initial gene list and info collated by Ian Berry Leeds Genetics Laboratory November 2018 on behalf of the GMS Respiratory specialist test group. Gene Symbol submitted: TTC25; Suggested initial gene rating: Green; Evidence for inclusion: OMIM PCD or Visceral heterotaxy gene; Evidence for exclusion: none given; Technical notes (e.g. non-coding/CNV mutations requiring coverage?): none given
Created: 5 Dec 2018, 12:52 p.m.
Tag new-gene-name tag was added to gene: TTC25.
Gene: ttc25 has been classified as Amber List (Moderate Evidence).
Phenotypes for gene: TTC25 were changed from to Ciliary dyskinesia, primary, 35, 617092
Publications for gene: TTC25 were set to
Mode of inheritance for gene: TTC25 was changed from to BIALLELIC, autosomal or pseudoautosomal
Source Expert Review Green was added to TTC25. Rating Changed from Red List (low evidence) to Green List (high evidence)
gene: TTC25 was added gene: TTC25 was added to Laterality disorders and isomerism. Sources: NHS GMS Mode of inheritance for gene: TTC25 was set to