Laterality disorders and isomerism


Amber List (moderate evidence)

FANCB (Fanconi anemia complementation group B)
EnsemblGeneIds (GRCh38): ENSG00000181544
EnsemblGeneIds (GRCh37): ENSG00000181544
OMIM: 300515, Gene2Phenotype
FANCB is in 25 panels

2 reviews

Zornitza Stark (Australian Genomics)

Red List (low evidence)

Not a laterality/heterotaxy disorder.
Created: 2 Jun 2020, 8:37 a.m. | Last Modified: 2 Jun 2020, 8:37 a.m.
Panel Version: 1.5

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Fanconi anemia, complementation group B, MIM# 300514

Louise Daugherty (Genomics England Curator)

I don't know

Initial gene list and info collated by Ian Berry Leeds Genetics Laboratory November 2018 on behalf of the GMS Respiratory specialist test group. Gene Symbol submitted: FANCB; Suggested initial gene rating: Amber; Evidence for inclusion: Possible VACTERL-H association, which can include isomerism (but this could be just ZIC3-associated); Evidence for exclusion: Unclear link to gene in any literature; Technical notes (e.g. non-coding/CNV mutations requiring coverage?): none given
Created: 5 Dec 2018, 12:52 p.m.

History Filter Activity

5 Dec 2018, Gel status: 2

Added New Source, Status Update

Louise Daugherty (Genomics England Curator)

Source Expert Review Amber was added to FANCB. Rating Changed from Red List (low evidence) to Amber List (moderate evidence)

5 Dec 2018, Gel status: 1

Created, Added New Source, Set mode of inheritance

Louise Daugherty (Genomics England Curator)

gene: FANCB was added gene: FANCB was added to Laterality disorders and isomerism. Sources: NHS GMS Mode of inheritance for gene: FANCB was set to