Laterality disorders and isomerism

Gene: LZTFL1

Amber List (moderate evidence)

LZTFL1 (leucine zipper transcription factor like 1)
EnsemblGeneIds (GRCh38): ENSG00000163818
EnsemblGeneIds (GRCh37): ENSG00000163818
OMIM: 606568, Gene2Phenotype
LZTFL1 is in 16 panels

1 review

Louise Daugherty (Genomics England Curator)

I don't know

Initial gene list and info collated by Ian Berry Leeds Genetics Laboratory November 2018 on behalf of the GMS Respiratory specialist test group. Gene Symbol submitted: LZTFL1; Suggested initial gene rating: Amber; Evidence for inclusion: BBS17 in OMIM; rare reports of dextrocardia; Evidence for exclusion: Laterality abnormalities seen in <2% of BBS patients (CRIBBS), disorder is syndromic and otherwise recognisable; polydactyly/delay more prominent early features.; Technical notes (e.g. non-coding/CNV mutations requiring coverage?): none given
Created: 5 Dec 2018, 12:52 p.m.

History Filter Activity

5 Dec 2018, Gel status: 2

Added New Source, Status Update

Louise Daugherty (Genomics England Curator)

Source Expert Review Amber was added to LZTFL1. Rating Changed from Red List (low evidence) to Amber List (moderate evidence)

5 Dec 2018, Gel status: 1

Created, Added New Source, Set mode of inheritance

Louise Daugherty (Genomics England Curator)

gene: LZTFL1 was added gene: LZTFL1 was added to Laterality disorders and isomerism. Sources: NHS GMS Mode of inheritance for gene: LZTFL1 was set to