Pigmentary skin disorders
Gene: TSC2
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
TUBEROUS SCLEROSIS 2; TSC2
Publications
Variants in this gene are a cause of Tuberous Sclerosis which is characterised by pigmentary abnormalities, classically hypomelanotic macules and confetti skin lesions, among other features.Created: 17 Apr 2019, 6:29 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Tuberous sclerosis-2
This gene was part of an initial gene list collated by Thomas Cullup, GOSH and Veronica Kinsler, UCL, 25.Jan.2019 on behalf of the GMS Skin Specialist Test Group. Gene Symbol submitted: TSC2; Suggested initial gene rating: Green; Evidence for inclusion: none provided; Evidence for exclusion: none provided; Technical notes (e.g. non-coding/CNV mutations requiring coverage?): none provided.Created: 31 Jan 2019, 11:31 a.m.
Added phenotypes TUBEROUS SCLEROSIS 2; TSC2 for gene: TSC2 Publications for gene TSC2 were changed from to 12111193
Source London North GLH was added to TSC2.
gene: TSC2 was added gene: TSC2 was added to Pigmentary skin disorders. Sources: Expert Review Green,NHS GMS Mode of inheritance for gene: TSC2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: TSC2 were set to Tuberous sclerosis