Endocrine neoplasia
Gene: MEN1EnsemblGeneIds (GRCh38): ENSG00000133895
EnsemblGeneIds (GRCh37): ENSG00000133895
OMIM: 613733, Gene2Phenotype
MEN1 is in 16 panels
5 reviews
Ivone Leong (Genomics England Curator)
Comment when marking as ready: As discussed in the GMS Endocrinology Specialist Test Group webex call 28th Jan 2019: The Specialist Test Group agreed that there is enough evidence to rate this gene green.Created: 11 Mar 2019, 2:04 p.m.
Louise IZATT (GSTT Clinical Genetics Service)
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Katie Snape (South London GMC)
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Variants in this GENE are reported as part of current diagnostic practice
Treena Cranston (Oxford)
Sian Ellard (University of Exeter Medical School)
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
- Sources
-
- Expert Review Green
- NHS GMS
- Phenotypes
-
- Endocrine Cancer
- pituitary tumours
- Multiple Endocrine Neoplasia Type 1: MEN1 Gene Deletion/Duplication
- Parathyroid adenoma, somatic
- Multiple endocrine neoplasia 1, 131100
- Carcinoid tumor of lung
- Angiofibroma, somatic
- Adrenal adenoma, somatic
- Lipoma, somatic
- MEN1-like spectrum
- Multiple Endocrine Neoplasia
- OMIM
- 613733
- Clinvar variants
- Variants in MEN1
- Penetrance
- None
- Panels with this gene
-
- Inherited phaeochromocytoma and paraganglioma
- Additional findings health related - children
- Familial Tumours Syndromes of the central & peripheral Nervous system
- Parathyroid Cancer
- Familial hyperparathyroidism or hypocalciuric hypercalcaemia
- Adult solid tumours for rare disease
- Childhood solid tumours
- Adult solid tumours cancer susceptibility
- Multiple endocrine tumours
- Endocrine neoplasia
- Additional findings health related - CNV analysis children
- Inherited phaeochromocytoma and paraganglioma excluding NF1
- Inherited non-medullary thyroid cancer
- Additional findings health related
- Neuroendocrine cancer pertinent cancer susceptibility
- Childhood solid tumours cancer susceptibility
History Filter Activity
Entity classified by Genomics England curator
Ivone Leong (Genomics England Curator)Gene: men1 has been classified as Green List (High Evidence).
Created, Added New Source, Set mode of inheritance, Set Phenotypes
Ivone Leong (Genomics England Curator)gene: MEN1 was added gene: MEN1 was added to Endocrine neoplasms. Sources: Expert Review Green,NHS GMS Mode of inheritance for gene: MEN1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: MEN1 were set to Endocrine Cancer; pituitary tumours; Multiple Endocrine Neoplasia Type 1: MEN1 Gene Deletion/Duplication; Parathyroid adenoma, somatic; Multiple endocrine neoplasia 1, 131100; Carcinoid tumor of lung; Angiofibroma, somatic; Adrenal adenoma, somatic; Lipoma, somatic; MEN1-like spectrum; Multiple Endocrine Neoplasia