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  2. Viral resistance
This Panel is marked as Internal

Viral resistance (Version 0.64)

Level 2: Viral research

Panel types: Research
Description
This panel was made internal in September 2025. It has not been actively maintained for several years and is therefore of little clinical use.


This gene panel is currently in progress. We encourage experts to review the genes to help establish a list of 'Green' (high level of evidence) genes for resistance to viral infection. Missing genes can be added to the panel by Reviewers, or please submit a list to [email protected]. 

This is a gene panel for research use. Therefore the evidence level required for a gene to be Green may be more inclusive than our guidelines for monogenic diseases.
Panel Activity

4 reviewers

  • Sarah Leigh (Genomics England Curator)

    Group: Other
    Workplace: Other

  • Rebecca Foulger (Genomics England curator)

    Group: Other
    Workplace: Other

  • Eleanor Williams (Genomics England Curator)

    Group: Other
    Workplace: Other

  • Ivone Leong (Genomics England Curator)

    Group: Other
    Workplace: Other

24 Entities

23 reviewed, 7 green

List Entity Reviews Mode of inheritance Details
24 Entitiess
Green List (high evidence)
CCR5
1 review
 BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Sources
  • Expert list
  • Expert Review Green
  • Literature
Phenotypes
  • {Hepatitis C virus, resistance to}, 609532
  • {HIV infection, susceptibility/resistance to}
Tags
Green List (high evidence)
CXCR1
1 review
 Unknown
Sources
  • Expert Review Green
  • OMIM
Phenotypes
  • {AIDS, slow progression to} 609423
Tags
Green List (high evidence)
FUT2
1 review
 BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert list
  • Expert Review Green
  • Literature
Phenotypes
  • {Norwalk virus infection, resistance to}
Tags
Green List (high evidence)
KIR3DL1
1 review
 Unknown
Sources
  • Expert Review Green
  • OMIM
Phenotypes
  • {AIDS, delayed/rapid progression to} 609423
Tags
Green List (high evidence)
LDLR
2 reviews
1 green 		MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Literature
Phenotypes
  • Hypercholesterolemia, familial, 1 143890
  • LDL cholesterol level QTL2 143890
Tags
Green List (high evidence)
TLR3
1 review
 Unknown
Sources
  • Expert Review Green
  • OMIM
Phenotypes
  • {HIV1 infection, resistance to} 609423
Tags
Green List (high evidence)
TNF
2 reviews
 Unknown
Sources
  • Expert Review Green
  • OMIM
Tags
Amber List (moderate evidence)
CXCL12
1 review
 Not set
Sources
  • Expert Review Amber
  • OMIM
Phenotypes
  • {AIDS, resistance to} 609423
Tags
Amber List (moderate evidence)
DDX58
2 reviews
 Unknown
Sources
  • Expert Review Amber
  • Literature
Tags
  • new-gene-name
Amber List (moderate evidence)
MX1
2 reviews
 Unknown
Sources
  • Expert Review Amber
  • Literature
Tags
Red List (low evidence)
ACKR1
1 review
 Unknown
Sources
  • Expert list
  • Expert Review Red
  • Literature
Phenotypes
  • {Malaria, vivax, protection against}, 611162
Tags
Red List (low evidence)
CCL11
1 review
1 red 		Unknown
Sources
  • Expert Review Red
  • Other
Phenotypes
  • {HIV1, resistance to} 609423
Tags
Red List (low evidence)
CCL2
1 review
 Not set
Sources
  • Expert Review Red
  • OMIM
Phenotypes
  • {HIV-1, resistance to} 609423
Tags
Red List (low evidence)
CCL3
0 reviews
 Not set
Sources
  • OMIM
Phenotypes
  • {HIV infection, resistance to} 609423
Tags
Red List (low evidence)
CD209
2 reviews
 Not set
Sources
  • OMIM
Phenotypes
  • {Dengue fever, protection against} 614371
Tags
Red List (low evidence)
CLEC4M
1 review
 Unknown
Sources
  • Expert Review Red
  • Other
Phenotypes
  • SARS infection, protection against, 605872
Tags
Red List (low evidence)
DPP4
1 review
1 red 		Unknown
Sources
  • Literature
Tags
Red List (low evidence)
HLA-B
1 review
 Unknown
Sources
  • Literature
Phenotypes
  • immunity to COVID-19
Tags
Red List (low evidence)
HLA-C
1 review
 Not set
Sources
  • OMIM
Phenotypes
  • {HIV-1 viremia, susceptibility to} 609423
Tags
Red List (low evidence)
HLA-DQB1
1 review
 Not set
Sources
  • OMIM
Tags
Red List (low evidence)
IFNG
1 review
 Unknown
Sources
  • OMIM
Phenotypes
  • {AIDS, rapid progression to} 609423
  • {Hepatitis C virus, response to therapy of}, 609532
Tags
Red List (low evidence)
IL22
1 review
 Unknown
Sources
  • Literature
Phenotypes
  • resistance to lethal West Nile virus
Tags
Red List (low evidence)
IL4R
2 reviews
 BIALLELIC, autosomal or pseudoautosomal
Sources
  • OMIM
Phenotypes
  • {AIDS, slow progression to} 609423
Tags
Red List (low evidence)
SELPLG
1 review
1 red 		Unknown
Sources
  • Literature
Tags

Downloads

Download lists

  • Whole panel
  • Green list (high evidence)
  • Green and Amber Genes
  • Amber Genes
  • Red list (low evidence)

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