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  2. IUGR and IGF abnormalities
  3. ORC1
STRs in panel
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IUGR and IGF abnormalities

Gene: ORC1

Green List (high evidence)
ORC1 (origin recognition complex subunit 1)
EnsemblGeneIds (GRCh38): ENSG00000085840
EnsemblGeneIds (GRCh37): ENSG00000085840
OMIM: 601902, Gene2Phenotype
ORC1 is in 9 panels

3 reviews

Peter Clayton (University of Manchester)

Green List (high evidence)

Created: 5 Nov 2017, 2:41 a.m.

Panel version: 0

Philip Murray (University of Manchester)

Green List (high evidence)

Created: 5 Nov 2017, 2:41 a.m.

Panel version: 0

emma baple (Genomics England Curator)

Comment on phenotypes: Meier Gorlin syndrome
Created: 3 Apr 2016, 8:20 p.m.
Created: 3 Apr 2016, 8:20 p.m.

Panel version: 0.77

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
Phenotypes
  • Meier-Gorlin syndrome 1, OMIM:224690
  • microtia, beaked nose, patellar aplasia/hypoplasia, mammary hypoplasia, micrognathia
OMIM
601902
Clinvar variants
Variants in ORC1
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

26 Apr 2024, Gel status: 3

Set Phenotypes

Arina Puzriakova (Genomics England Curator)

Phenotypes for gene: ORC1 were changed from microtia, beaked nose, patellar aplasia/hypoplasia, mammary hypoplasia, micrognathia to Meier-Gorlin syndrome 1, OMIM:224690; microtia, beaked nose, patellar aplasia/hypoplasia, mammary hypoplasia, micrognathia

3 Apr 2016, Gel status: 4

Gene classified by Genomics England curator

emma baple (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

3 Apr 2016, Gel status: 4

Set Phenotypes

emma baple (Genomics England Curator)

Phenotypes for ORC1 were set to microtia, beaked nose, patellar aplasia/hypoplasia, mammary hypoplasia, micrognathia

3 Apr 2016, Gel status: 4

Gene classified by Genomics England curator

emma baple (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

23 Oct 2015, Gel status: 0

Added New Source

Philip Murray (University of Manchester)

ORC1 was added to IUGR and IGF abnormalitiespanel. Sources: Literature

23 Oct 2015, Gel status: 0

Created

Philip Murray (University of Manchester)

ORC1 was created by PhilMurray